AI Article Synopsis
- The study focuses on the impact of persistent bacterial gastroenteritis in children, revealing that 45.5% of participants experienced at least one persistent episode during the research period.
- Persistent infections were defined as three or more consecutive months of positive test results, with affected children showing an average of 150 days of positive symptoms.
- While persistent infections did not significantly affect short-term weight gain, they were linked to a decrease in linear growth over nine months, indicating a serious health risk for young children.
Article Abstract
Background: is the leading cause of bacterial gastroenteritis worldwide. It is generally associated with an acute gastrointestinal infection causing a self-limiting diarrheal episode. However, there is evidence that persistent/recurrent carriage of also occurs. In hyperendemic settings the epidemiology and consequences of persistent enteric infections is poorly studied.
Methods: Risk factors for and growth consequences of persistent infections detected by polymerase chain reaction (qPCR) were evaluated with data from the MAL-ED birth cohort study in children 0-24 months of age between November 2009 and February 2012. A persistent infection was defined as three or more consecutive positive monthly stools.
Findings: Across all study sites, 45.5% (781/1715) of children experienced at least one persistent episode. The average cumulative duration of days in which children with persistent were positive for spp. was 150 days (inter-quartile range: 28-236 days). Children who experienced a persistent episode had an attained 24-month length-for-age (LAZ) score that was 0.23 (95% (CI): -0.31, -0.15) less than children without a persistent episode. Among children who had at least one episode of over a 3-month or 9-month window, persistent episodes were not significantly associated with poorer 3-month weight gain (-28.7 g, 95% CI: -63.4 g, 6.0 g) but were associated with poorer 9-month linear growth (-0.134 cm 95% CI: -0.246, -0.022) compared to children with an episode that resolved within 31 days.
Interpretation: Persistent/recurrent infection is common among children and has a measurable negative impact on linear growth in early childhood.
Funding: Funding for this study was provided by the Bill and Melinda Gates Foundation (OPP1066146 and OPP1152146), the National Institutes of Health United States (R01AI158576 and R21AI163801 to MNK and CTP; K43TW012298 to FS; K01AI168493 to JMC; GOL was supported by K01AI145080. This research was also supported in part by USDA-ARS CRIS project 2030-42000-055-00D. The funders had no role in study design, study implementation, data analysis, or interpretation of the results.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460251 | PMC |
| http://dx.doi.org/10.1016/j.eclinm.2024.102841 | DOI Listing |
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