Schizophrenia is among the most devastating and costly human diseases. The public face of the failure to appropriately treat schizophrenia includes approximately 100,000 homeless individuals with schizophrenia and related psychoses and 200,000 incarcerated individuals with similar diagnoses. Clozapine and long-acting injectable antipsychotics are among the most effective treatments, but both are markedly underused. The following organizations should take responsibility for fixing this problem: National Institute of Mental Health, Patient-Centered Outcomes Research Institute, Substance Abuse and Mental Health Services Administration, Centers for Medicare and Medicaid Services, U.S. Food and Drug Administration, American Psychiatric Association, and patient and family advocacy groups.
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| http://dx.doi.org/10.1176/appi.ps.20240110 | DOI Listing |
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Background: Antipsychotics are recommended after first-episode psychosis. Knowledge on the current use patterns in real-world settings is thus important to inform clinical practice. We aimed to describe antipsychotic initiation during 1 year after first-episode psychosis and its associated factors.
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Department of Forensic Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
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- Psychopharmacotherapy is crucial for treating mentally disordered offenders (MDOs) with schizophrenia in Japan, highlighting a lack of large-scale research in forensic settings.
- The study analyzed data from 362 MDOs across 32 forensic psychiatric wards, focusing on the use of antipsychotic medications, particularly clozapine and long-acting injections (LAIs).
- Findings showed that clozapine and LAIs were used in about 23% and 25% of cases, respectively, with clozapine linked to higher seclusion rates and longer hospital stays, indicating a need for further research on medication impacts in this population.
Chronic olanzapine treatment leads to increased opioid receptor expression and changes in feeding regulating neurons in the female rat hypothalamus.
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Core Centre for Molecular Morphology, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.
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- * The study involved female rats treated with olanzapine, revealing immediate increases in eating (hyperphagia) and continued weight gain, alongside specific changes in opioid receptor expression in the hypothalamus.
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What is the neurobiology of schizophrenia?
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University of California, San Diego, CA, USA.
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Multi-level barriers and facilitators to implementing evidence-based antipsychotics in the treatment of early-phase schizophrenia.
Front Health Serv
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Department of Psychiatry and Behavioral Sciences and Center for Dissemination and Implementation Science, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Introduction: Long-acting injectable (LAI) antipsychotic medications and clozapine are effective yet underutilized medical therapies in early intervention services. The purpose of this study was to conduct a pre-implementation evaluation of contextual determinants of early intervention programs to implement innovations optimizing LAI antipsychotic and clozapine use within a shared decision-making model.
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