AI Article Synopsis
- The study aimed to evaluate how electroacupuncture (EA) helps maintain brain plasticity after ischemic stroke damage.
- Researchers analyzed 101 studies involving 2,148 animals, using tools to assess quality and conduct a meta-analysis of their findings.
- Results showed that EA significantly improved brain structure and function in ischemic stroke rats, indicating its potential role in enhancing recovery through brain plasticity; however, the authors call for more rigorous future studies.
Article Abstract
Objective: To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage.
Methods: We searched for all relevant trials published through Oct 7, 2022 from seven databases. Metho-dological quality was assessed using the CAMARADES Risk of Bias Tool. A Meta-analysis of comparative effects was performed using Review Manager v.5.3 software.
Results: A total of 101 studies involving 2148 animals were included. For most studies, primary outcomes results of the Meta-analysis indicate that EA significantly improved ischemic stroke rat's postsynaptic density thickness [Standardized Mean Difference () = 1.41, 95% confidence interval () (0.59, 2.23), 0.0008], numerical density of synapses [ = 1.55, 95% (0.48, 2.63), 0.005] compared with non-EA-treated. Similarly, EA could improve parts of biomarkers of synapses, neurogenesis, angiogenesis and neurotrophin activity than the control group ( 0.05).
Conclusion: The existing evidence suggests EA regulating ischemic stroke may be through brain plasticity. More rigorous and high quality studies should be conducted in the future.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462533 | PMC |
| http://dx.doi.org/10.19852/j.cnki.jtcm.20240828.008 | DOI Listing |
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