AI Article Synopsis
- Osteoporosis patients often suffer from vertebral compression fractures (VCF), impacting their quality of life and increasing the risk of further fractures, making accurate diagnosis essential for treatment.
- The study involved 34 patients with VCF who underwent bone imaging, measuring the maximum standard uptake value (SUVmax) of fresh and old fractures, as well as normal vertebrae, to assess the diagnostic value of the technique.
- The findings revealed that fresh VCFs had a significantly higher SUVmax (19.80) compared to other groups, with a recommended cut-off value of 9.925 for diagnosis, suggesting bone SPECT/CT is effective in detecting fresh VCF and evaluating fracture severity.
Article Abstract
Background: Most patients with osteoporosis experience vertebral compression fracture (VCF), which significantly reduces their quality of life. These patients are at a high risk of secondary VCF regardless of treatment. Thus, accurate diagnosis of VCF is important for treating and preventing new fractures. We aimed to investigate the diagnostic and predictive value of quantitative bone imaging techniques for fresh VCF.
Methods: From November 2021 to March 2023, 34 patients with VCF were enrolled in this study, all of whom underwent routine Tc-MDP whole-body bone planar scan and local SPECT/CT imaging. The maximum standard uptake value (SUVmax) of 57 fresh VCF, 57 normal adjacent vertebrae, and 19 old VCF were measured. Based on the site of the fracture, fresh VCFs were regrouped into the intervertebral-type group and the margin-type group. Meanwhile, 52 patients who had no bone metastasis or VCFs in their bone scan were assigned to the control group. The SUVmax of 110 normal vertebral bodies and 10 old VCFs in the control group were measured.
Results: The median SUVmax of fresh VCF was 19.80, which was significantly higher than the SUVmax of other groups. The receiver operator characteristic (ROC) curve showed that the cut-off value of SUVmax was 9.925 for diagnosing fresh VCF. The SUVmax in the intervertebral-type group was significantly higher than that in the margin-type group (P = 0.04). The SUVmax of normal vertebrae was higher among patients than among the control group (P<0.01), but the CT HU value showed no significant difference.
Conclusion: The quantitative technique of bone SPECT/CT has a significant value in diagnosing fresh VCF. It can also determine the severity of fractures. In addition, whether the SUVs of the vertebrae adjacent to the fractured vertebra can predict re-fracture deserves further studies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459896 | PMC |
| http://dx.doi.org/10.1186/s12880-024-01452-9 | DOI Listing |
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