High-steep gently inclined mining slopes, prevalent globally, often suffer significant deformation, leading to landslides due to numerous goafs. This research investigates the critical role of goaf location in controlling deformation, failure mechanisms, and disaster evolution, vital for safe mining practices. Through field investigations and model generalization in Guizhou, a physical model test method was used to study three positions of goafs: under the shoulder and foot of the slope, under the slope shoulder, and within the slope. Findings highlight the stronger influence of the goaf's mutual position with the slope shoulder on slope and overburden deformation and failure compared to the slope toe. Deformation and failure modes evolve from collapse toppling to collapse slip and collapse settlement as the goaf shifts from the near slope surface to inside of the slope. Statistical analysis of fracture distribution in the goaf's overlying strata reveals damage increase with larger goafs, following a Gaussian distribution, with concentrated damage in the middle. The study identifies the maximum damage area, influenced by the horizontal distance between the goaf center and slope shoulder. These insights advance understanding of overburden rock deformation in gently inclined high-steep mining slopes.
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http://dx.doi.org/10.1038/s41598-024-74499-x | DOI Listing |
Eur J Pediatr
January 2025
Neonatology Department. Hospital Sant Joan de Déu, Center for Maternal Fetal and Neonatal Medicine. Neonatal Brain Group, Universitat de Barcelona. Hospital Clínic, Universitat de Barcelona. BCNatal - Barcelona, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
Purpose: Perinatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of neonatal brain injury. Therapeutic hypothermia (TH) is the standard treatment for term neonates, but its safety and efficacy in neonates < 36 weeks gestational age (GA) remains unclear. This case series aimed to evaluate the outcomes of preterm infants with HIE treated with TH.
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Liver Unit, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada.
Cirrhotic cardiomyopathy is defined as systolic and diastolic dysfunction in patients with cirrhosis, in the absence of any primary heart disease. These changes are mainly due to the malfunction or abnormalities of cardiomyocytes. Similar to non-cirrhotic heart failure, cardiomyocytes in cirrhotic cardiomyopathy demonstrate a variety of abnormalities: from the cell membrane to the cytosol and nucleus.
View Article and Find Full Text PDFCureus
December 2024
Department of Orthopaedics and Traumatology, All India Institute of Medical Sciences, Raipur, Raipur, IND.
Knee pain in patients often involves varus deformity and unicompartmental osteoarthritis (OA). High tibial valgus osteotomy (HTO) is increasingly recognized as an effective treatment, as it realigns the knee's mechanical axis towards the healthier lateral compartment, delaying degenerative changes in the medial compartment and reducing the need for joint replacement. This case report discusses two patients with bilateral knee arthritis and varus deformity who underwent medial opening-wedge high tibial osteotomy (MOWHTO) using Dr.
View Article and Find Full Text PDFBiomech Model Mechanobiol
December 2024
Bioengineering, University of California, Santa Barbara, Santa Barbara, United States.
The heart is a dynamic pump whose function is influenced by its mechanical properties. The viscoelastic properties of the heart, i.e.
View Article and Find Full Text PDFCancer Med
January 2025
Department of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Athens, Georgia, USA.
Introduction: Emerging evidence suggests potential cardiovascular toxicities from oral endocrine therapies (ETs); however, results are conflicting. This study comprehensively examined adverse reactions of ETs and investigated cardiovascular and metabolic safety signals within the FDA Adverse Event Reporting System (FAERS).
Methods: Reports in the FAERS through December 2023 were analyzed for documented reactions to tamoxifen, letrozole, anastrozole, and exemestane in female breast cancer patients.
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