AI Article Synopsis
- - The study explored the link between liver fibrosis and chronic kidney disease (CKD) in patients with metabolic-associated fatty liver disease (MAFLD) by comparing 84 MAFLD patients with CKD to 80 without CKD.
- - Findings revealed that CKD patients had a significantly higher rate of liver fibrosis (75.6%) versus non-CKD patients (24.4%), with various health conditions such as diabetes and hypertension identified as risk factors for CKD.
- - The research concluded that CKD may increase the risk of liver fibrosis in MAFLD patients, highlighting independent factors like age and levels of certain substances in the blood that are linked to CKD development.
Article Abstract
Objectives: To examine the relation between liver fibrosis and chronic kidney disease (CKD) in metabolic-associated fatty liver disease (MAFLD) patients and its risk factors.
Methods: The current study was carried out at Tanta University Hospital, Tanta, Egypt, from May 2021 to January 2023 and included 84 MAFLD patients with CKD and 80 MAFLD patients without CKD. All participants had been examined by abdominal ultrasonography and transient elastography with controlled attenuation parameter.
Results: Chronic kidney disease patients exhibited a greater incidence of fibrosis compared to patients without CKD (75.6% vs. 24.4%). Logistic analysis demonstrated that the presence of multiple health conditions, such as MAFLD, diabetes mellitus, hypertension, and cardiovascular disease, were individually linked to CKD. Gender and body mass index were not independent factors related to CKD. Additionally, factors such as age, hyperuricemia, hypertriglyceridemia, hypercholesterolemia, hypoalbuminemia, hyperbilirubinemia, and viral hepatitis, apart from MAFLD comorbidities, were independently linked to CKD.
Conclusion: Chronic kidney disease may represent a potential risk influence for liver fibrosis development in MAFLD patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463562 | PMC |
| http://dx.doi.org/10.15537/smj.2024.45.10.20240393 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.
J Cell Mol Med
March 2025
Department of Cardiology, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Recent research has revealed a close association between obesity and various metabolic disorders, including renal metabolic diseases, but the mechanism is still unknown. This study explored the role of p16INK4a in obesity-related kidney fibrosis and evaluated its potential as a therapeutic target. Using wild-type (WT) mice and p16 KO mice, we fed both groups a high-fat diet (HFD) for 6 months.
View Article and Find Full Text PDFTrimethylamine N-Oxide Plasma Levels Following Red Meat and Cod Fish Intake: A Pilot Crossover Trial in Hemodialysis Patients.
Mol Nutr Food Res
March 2025
Graduate Program in Food, Nutrition and Health - Institute of Nutrition, State University of Rio de Janeiro (UERJ), Rio de Janeiro (RJ), Brazil.
Scope: The uremic toxin trimethylamine N-oxide (TMAO) accumulates in patients with chronic kidney disease (CKD) and is associated with its progression, cardiovascular disease, and other complications. The gut microbiota produces TMAO from substrates mainly found in red meat, eggs, and dairy. However, some saltwater fish also contain high levels of TMAO.
View Article and Find Full Text PDFAssessment of unrecognized myocardial infarction using cardiac magnetic resonance imaging in patients with endstage renal disease.
Radiol Bras
February 2025
Department of Radiology, Medical Faculty, Ataturk University, Erzurum, Turkey.
Objective: To assess the frequency of unrecognized myocardial infarction and identify additional ischemic conditions, as well as to evaluate the efficacy of cardiac magnetic resonance imaging (CMRI) in risk groups, comparing the imaging findings with electro-cardiographic (ECG) and laboratory data in patients with stage 5 chronic kidney disease, also known as end-stage renal disease.
Materials And Methods: This was a prospective single-center study involving 20 patients who were referred to our radiology department to undergo CMRI between June 2010 and December 2011. Resting left ventricular functions and (early and late) myocardial contrast enhancement were assessed in all patients.
Evaluating Risk in Kidney Living Donors.
Transpl Int
March 2025
Department of General Surgery, Demiroglu Bilim University and Group Florence Nightingale Hospital, Istanbul, Türkiye.
Kidney donation is a safe procedure for carefully screened donors. The growing shortage of organs and improved survival rates among recipients of living donor transplants have broadened the criteria for acceptable living donors, including older individuals and those with pre-existing health conditions. Consequently, ensuring both the short- and long-term safety of living donors is of paramount importance.
View Article and Find Full Text PDFAcute Kidney Injury Secondary to Fecaloma: A Rare Complication of Chronic Constipation.
ACG Case Rep J
March 2025
Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!