AI Article Synopsis
- Scientists have learned that controlled cell death is important in fighting cancer.
- Researchers are finding new ways to use special drugs called BH3-mimetics to help kill cancer cells.
- There are still challenges to overcome in using these drugs effectively, and scientists are working hard to solve these problems.
Article Abstract
From its earliest characterization, it has been recognized that there is a role for regulated (programmed) cell death in cancer. As our understanding of the different types of programmed cell death processes and their molecular control has advanced, so have the technologies that allow us to manipulate these processes to, for example, fight against cancer. In this review, we describe the roles of the different forms of regulated cell death in the development of cancer as well as their potential therapeutic exploitation. In that vein, we explore the development and use of BH3-mimetics, a unique class of drugs that can directly activate the apoptotic cell death machinery to treat cancer. Finally, we address key challenges that face the field to improve the use of these therapeutics and the efforts that are being undertaken to do so.
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| http://dx.doi.org/10.1016/j.devcel.2024.06.018 | DOI Listing |
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