Using scanning electron microscopy (SEM), a small animal imaging system, and biological tissue sections, the relationships between the flapping vibrations in the hindwings of Trypoxylus dichotomus and their morphology, structure, and hemolymph dynamics were investigated. Based on these findings, a three-degree-of-freedom (3-DOF) model incorporating nano-mechanical properties was developed to investigate spanwise passive synergistic vibration reduction (PSVR) in the hindwing elements. To ensure precision, the Runge-Kutta and incremental harmonic balance (IHB) methods were employed for both solving and comparing solutions. Analysis of the spanwise force (F) signals confirmed the validity of the PSVR model. Parametric analysis revealed that reducing system mass and stiffness increased the resonance amplitude while shifting the resonance frequency in the opposite direction. The resonance frequency and flexible deformation amplitude of the hindwing system could be controlled by adjusting mass and stiffness within the synergistic framework. The mass and damping of the wing base, along with the stiffness of the wing membrane, were identified as critical factors in the system. This model provides valuable insights into the PSVR mechanism, potentially informing the design and manufacture of bionic flexible flapping wings.
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http://dx.doi.org/10.1016/j.micron.2024.103725 | DOI Listing |
Clin Interv Aging
January 2025
Department of Nursing, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, People's Republic of China.
Purpose: This study aims to identify self-management behavior profiles in multimorbid patients, and explore how workload, capacity, and their interactions influence these profiles.
Patients And Methods: A sequential explanatory mixed-methods design was employed. In the quantitative phase (August 2022 to May 2023), data were collected from 1,920 multimorbid patients across nine healthcare facilities in Zhejiang Province.
Int J Nanomedicine
January 2025
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 116600, People's Republic of China.
Background: Ovarian cancer is difficult to detect in its early stages, and it has a high potential for invasion and metastasis, along with a high rate of recurrence. These factors contribute to the poor prognosis and reduced survival times for patients with this disease. The effectiveness of conventional chemoradiotherapy remains limited.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
Department of Chemistry, Northeast Normal University, Changchun 130024, PR China. Electronic address:
The oral administration of drugs for cancer therapy can maintain optimal blood concentrations, is biologically safe and simple, and is preferred by many patients. However, the complex lumen environment, mucus layer, and intestinal epithelial cells are biological barriers that hinder the absorption of orally administered drugs. In this study, sea urchin-like manganese-doped copper selenide nanoparticles (Mn-CuSe NPs) were designed using an anion exchange method and coated with calcium alginate and chitosan (AC) to form Mn-CuSe@AC capsules.
View Article and Find Full Text PDFJ Med Chem
January 2025
Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Rd., Nanchang, Jiangxi 330013, China.
With the dilemma of limited efficacy of individual therapies, it is crucial to develop innovative combination therapy systems to target the complex pathogenesis of cancer. In this study, we designed a nanoprodrug ISL@MIL-101-ADT to facilitate synergistic delivery of hydrogen sulfide (HS) and prodrug ISL for specific eradication of tumor cells with minimal toxicity and maximal efficacy. The nanoprodrug passively targeted tumors through enhanced permeation and retention effects, followed by disintegration and release of IR780, lonidamine (LND), and HS.
View Article and Find Full Text PDFAntibiotics (Basel)
December 2024
Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
Previously, we reported that 3--alkyl difluoroquercetins (di-F-Q) potentiates the antimicrobial activity of aztreonam (ATM) against metallo-β-lactamase (MBL)-producing through simultaneous inhibition of MBLs and efflux pumps. However, the ATM-potentiating activity of the 3--alkyl di-F-Q was observed only at high and potentially toxic concentrations (32 mg/L). As both MBLs and efflux pumps reside in the periplasm of Gram-negative bacteria, their inhibitors should accumulate in the periplasmic space.
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