AI Article Synopsis
- * This systematic review analyzed 12 randomized studies involving 754 NP patients, assessing the impact of PRP injections compared to other treatments or placebos.
- * The findings indicated that PRP improved pain intensity in 8 out of 12 studies with a high safety profile, suggesting it may be a viable treatment for various NP conditions, although results should be interpreted carefully due to the limited representation of NP types.
Article Abstract
Background: Neuropathic pain (NP) has a considerable impact on the global economic burden and seriously impairs patients' quality of life. Currently there is no evidence-based "effective" treatment and new treatments are needed. Recently, platelet rich plasma (PRP) has emerged as an alternative treatment. Therefore, a systematic review has been conducted to present an evidence-based assessment of the use of PRP in the treatment of NP.
Methods: Randomized studies that investigated the effect of PRP injection on patients with NP compared to alternative treatments or placebo were included. An encompassing search of specific databases, from their inception to April 2024, was performed. The databases were as follows: PubMed, Web of Sciences (MEDLINE) and Cochrane Library. The Cochrane Risk-of-Bias 2 tool was used to assess study methodological quality.
Results: A total of 12 randomized studies with 754 patients with different NP conditions were included in this systematic review. According to the results from the qualitative analysis, PRP injection exerted a positive effect on improving pain intensity on most of the trials (8 out of 12). In the remaining studies, no differences were found. A high safety profile was reported with no serious adverse effects in the analysed patients.
Conclusion: PRP treatment might be an effective therapeutic approach for patients with different neuropathic pain conditions. The efficacy of PRP was not dependant on the aetiology of the underlying disorder; nevertheless, interpretations of the results should be performed cautiously, as for the under-representation of NP conditions.
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| http://dx.doi.org/10.1016/j.biopha.2024.117507 | DOI Listing |
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