AI Article Synopsis
- Periodontitis is a global oral health issue that hasn’t seen a decline despite prevention efforts, potentially linked to DNA damage-induced cellular senescence.
- SIRT7, an important protein with deacetylase activity, is found to be downregulated in human periodontal ligament fibroblasts when exposed to inflammatory bacteria, which leads to increased senescence and inflammation.
- Overexpression of the SIRT7 gene inhibits the production of related senescence molecules and inflammatory cytokines, suggesting that targeting SIRT7 could be a promising approach for treating periodontitis.
Article Abstract
Periodontitis seriously affects oral health worldwide. Despite extensive efforts in prevention and treatment methods over the years, the prevalence of periodontitis in the population has not decreased. DNA damage-induced cellular senescence may be one of the mechanisms underlying periodontitis.Sirtuin7 (SIRT7) has deacetylase activity and regulates a variety of biological processes, including cell proliferation, death, and DNA damage repair.Increasing evidence confirms the crucial role of SIRT7 in age-related and inflammatory diseases. However, the mechanism of action of SIRT7 in periodontitis remains unclear. Our study demonstrates that SIRT7 is downregulated in human periodontal ligament fibroblasts induced by Porphyromonas gingivalis lipopolysaccharide (Pg-LPS). Overexpression of the SIRT7 gene significantly reduces the production of senescence-related molecules P53, P21, P16, as well as inflammatory cytokines IL-1β and TNF-α stimulated by Pg-LPS. Furthermore, overexpression of the SIRT7 gene significantly decreases the phosphorylation levels of AKT and mTOR in Pg-LPS-treated hPDLFs. Conversely, SIRT7 gene knockdown exhibits opposite effects compared to overexpression in Pg-LPS-treated hPDLFs. In conclusion, our findings indicate that SIRT7 can inhibit Pg-LPS-induced senescence and consequently suppress the secretion of inflammatory cytokines through the AKT/mTOR pathway. As a result, SIRT7 could be regarded a viable pharmaceutical target for clinical periodontitis treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.intimp.2024.113300 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
PMAIP1-mediated glucose metabolism and its impact on the tumor microenvironment in breast cancer: Integration of multi-omics analysis and experimental validation.
Transl Oncol
December 2024
Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address:
Background: Glucose metabolism in breast cancer has a potential effect on tumor progression and is related to the immune microenvironment. Thus, this study aimed to develop a glucose metabolism-tumor microenvironment score to provide new perspectives on breast cancer treatment.
Method: Data were acquired from the Gene Expression Omnibus and UCSC Xena databases, and glucose-metabolism-related genes were acquired from the Gene Set Enrichment Analysis database.
Mechanistic insights into SIRT7 and EZH2 regulation of cisplatin resistance in bladder cancer cells.
Cell Death Dis
December 2024
Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Urology, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Cisplatin (CDDP) resistance has been established to significantly impact Bladder Cancer (BCa) therapy. On the other hand, the crucial regulatory involvement of SIRT7 and EZH2 in bladder cancer development is well known. Herein, the collaborative regulatory roles and underlying mechanisms of SIRT7 and EZH2 in CDDP resistance in bladder cancer were explored.
View Article and Find Full Text PDFInvestigation the role of SIRT3, SIRT7, NFATC1, and PDL-1 genes in androgenetic alopecia.
BMC Res Notes
November 2024
Department of Medical Genetic, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Background: Androgenetic alopecia (AGA) stands as the most prevalent form of hair loss, affecting the hair follicles (HFs). Aging emerges as a prominent contributor in this condition. In this study, our aim is to elucidate the expression patterns of candidate genes-SIRT3, SIRT7, NFATC1, and PDL-1-known to exhibit differential expression levels during HF aging, and to underscore the role of aging in AGA.
View Article and Find Full Text PDFSIRT7 stabilizes β-catenin and promotes canonical Wnt activation via upregulating FZD7.
Life Sci
December 2024
The Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, The Key Laboratory of Model Animals and Stem Cell Biology of Hunan Province, and Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Hunan Normal University School of Medicine, Changsha, Hunan 410013, China; Institute of Interdisciplinary Studies, Hunan Normal University, Hunan 410081, China. Electronic address:
Aims: The dysregulated Wnt/β-Catenin signaling pathway leads to occurrence of various diseases, and abnormal activation of β-Catenin is a major characteristic of human HCC. FZD7 is a positive regulator of the Wnt/β-catenin signaling pathway, and its upregulation is related to increase of β-catenin expression and carcinogenesis in human HCC. However, mechanisms underlying FZD7 upregulation in HCC remain elusive.
View Article and Find Full Text PDFSIRT7 inhibits the aging and inflammatory damage of hPDLFs by suppressing the AKT/mTOR.
Int Immunopharmacol
December 2024
School of Stomatology, Guizhou Medical University, Guiyang 550004, Guizhou Province, PR China; Department of Prosthodontics, The Affiliated Stomatology Hospital of Guizhou Medical University, Guiyang 550004, Guizhou Province, PR China. Electronic address:
Article Synopsis
- Periodontitis is a global oral health issue that hasn’t seen a decline despite prevention efforts, potentially linked to DNA damage-induced cellular senescence.
- SIRT7, an important protein with deacetylase activity, is found to be downregulated in human periodontal ligament fibroblasts when exposed to inflammatory bacteria, which leads to increased senescence and inflammation.
- Overexpression of the SIRT7 gene inhibits the production of related senescence molecules and inflammatory cytokines, suggesting that targeting SIRT7 could be a promising approach for treating periodontitis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!