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Alzheimers Dement
December 2024
Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Manganese (Mn) is an essential metal that serves as a cofactor for metalloenzymes important in moderating the glutamate/glutamine cycle and other oxidative stress pathways. Typically, Mn is acquired through the diet, however, Mn overexposure can arise through drinking inadequately treated well water or inhalation of Mn-containing industrial byproducts. Mn toxicity disrupts dopaminergic neurotransmission resulting in a Parkinsonian disorder referred to as manganism.
View Article and Find Full Text PDFRelease of Crystalline Silica Nanoparticles during Engineered Stone Fabrication.
ACS Omega
December 2024
Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH) Centers for Disease Control and Prevention (CDC),1090 Tusculum Ave,Cincinnati, Ohio 45226, United States.
Inhalation exposure to respirable crystalline silica (RCS) during the fabrication of engineered stone-based kitchen countertops has been on the rise in recent years and has become a significant occupational health problem in the United States and globally. Little is known about the presence of nanocrystalline silica (NCS), i.e.
View Article and Find Full Text PDFDevelopment of a dual PM sampling and direct exposure system incorporated an in vitro air-liquid interface culture method: Application to the northern Thailand haze season.
Environ Pollut
December 2024
Biomedical Engineering Institute, Chiang Mai University, Chiang Mai, 50200, Thailand; Biomedical Engineering and Innovation Research Center, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:
Exposure to ambient air pollution is associated with several noncommunicable diseases, and it adversely affects the respiratory system and other organ systems. Several studies have investigated the underlying mechanisms of biological response to air pollutants using conventional techniques, but there is a lack of research on the effects of air pollution at the cellular level. This study developed a dual system that combines PM (particulate matter <2.
View Article and Find Full Text PDFA New Perspective for Improving COPD: Ginsenoside Rg3 Links SIRT1 to Inhibit Mitochondrial Autophagy.
Discov Med
December 2024
Department of Respiratory Medicine, The First Affiliated Hospital of Anhui University of Chinese Medicine, 230031 Hefei, Anhui, China.
Background: Chronic obstructive pulmonary disease (COPD) is a prevalent yet manageable respiratory condition. However, treatments presently used normally have side effects and cannot cure COPD, making it urgent to explore effective medications. The ginsenoside Rg3 (Rg3) has been shown to have anti-inflammatory and anti-tumor properties and can improve COPD.
View Article and Find Full Text PDFPharmacometabolomics via real-time breath analysis captures metabotypes of asthmatic children associated with salbutamol responsiveness.
iScience
December 2024
Department of Biomedical Engineering, University of Basel, 4123 Allschwil, Switzerland.
Asthma is a widespread respiratory disease affecting millions of children. Salbutamol is a well-established bronchodilator available to treat asthma. However, response to bronchodilators is very heterogeneous, particularly in children.
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