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Controversies in smoldering multiple myeloma: finding the optimal approach for treatment initiation.
Oncologist
October 2024
Department of Medicine I, Center for Oncology, Hematology with Outpatient Department, and Palliative Care, Clinic Ottakring, 1160 Vienna, Austria.
Clinician preferences on treatment of smoldering myeloma: a cross-sectional survey.
EClinicalMedicine
November 2023
Section of Hematology/Oncology, University of Chicago, USA.
Background: Smoldering myeloma (SMM) is an asymptomatic precursor condition to multiple myeloma (MM) with a variable risk of progression. The management of high-risk SMM (HR-SMM) remains controversial, particularly with changes in diagnostic criteria that led to reclassifying of some patients with SMM to MM. This study aimed to assess clinician preferences for whether to treat patients with HR-SMM and/or patients with MM diagnosed solely by SLiM criteria (free light chain ratio >100, bone marrow plasma cell percentage >60, greater than two focal marrow lesions on MRI) through an electronic survey.
View Article and Find Full Text PDFModel analysis of post-fire management and potential reburn fire behavior.
J Environ Manage
February 2024
US Forest Service, Pacific Northwest Research Station, 400 North 34th Street, Suite 201, Seattle, WA, 98103, USA; University of Washington, Seattle, School and Environmental and Forest Sciences, PO Box 352100, Seattle, WA, 98195, USA.
Recent trends in wildfire area burned have been characterized by large patches with high densities of standing dead trees, well outside of historical range of variability in many areas and presenting forest managers with difficult decisions regarding post-fire management. Post-fire tree harvesting, commonly called salvage logging, is a controversial management tactic that is often undertaken to recoup economic loss and, more recently, also to reduce future fuel hazard, especially when coupled with surface fuel reduction. It is unclear, however, whether the reductions in future fuels translate to meaningful changes to reburn fire behavior, particularly in the context of potentially detrimental effects of harvest on other ecosystem services.
View Article and Find Full Text PDFThe effect of intervention versus watchful waiting on disease progression and overall survival in smoldering multiple myeloma: a systematic review of randomized controlled trials.
J Cancer Res Clin Oncol
April 2022
Department of Medicine, Hematology/Oncology Division, Howard University Hospital, Washington, DC, USA.
Background: Smoldering multiple myeloma (SMM) is an intermediate pre-malignant condition with individuals having a distinct risk of progression to overt myeloma. The optimal management option has remained controversial due to the heterogeneous nature of the condition in which progression to overt diseases is variable. The question of who, when, and what to use for the treatment of SMM remains equivocal.
View Article and Find Full Text PDF[Controversies in neurology: Diagnosis, follow up and therapy of multiple sclerosis with pathomechanismal approach].
Ideggyogy Sz
July 2021
Szegedi Tudományegyetem, ÁOK, Neurológiai Klinika, Interdiszciplináris Kiválóság Centrum, MTA-SZTE Idegtudományi Kutatócsoport, Szeged.
The clinical boundaries between the relapsing and progressive course of multiple sclerosis are often indistinct. Despite the variable patterns of evolution, there are no biological reasons for discerning different multiple sclerosis phenotypes. Indeed, both primary progressive and secondary forms of the disease share similar pathological features in respect of the extent of inflammatory infiltrates, axonal damage, and cortical demyelination.
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