AI Article Synopsis
- * In HFpEF patients, factors like obesity and heart conditions can cause increased pressure in the heart due to the restrictive nature of the pericardium.
- * Research is exploring the potential of pericardiotomy (surgical removal of the pericardium) as a new treatment option for HFpEF.
Article Abstract
The pericardium plays an important role in modulating cardiac performance and hemodynamics in patients with heart failure with preserved ejection fraction (HFpEF). Pericardial constraint increases filling pressures in patients with HFpEF, particularly those with the obesity phenotype, atrial myopathy, right ventricular dysfunction, and tricuspid regurgitation. Preclinical and early stage clinical studies indicate that pericardiotomy may become a novel treatment for HFpEF. This review summarizes and discusses the pathophysiology of pericardial restraint and the possibility of pericardiotomy in HFpEF.
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| http://dx.doi.org/10.1007/s10741-024-10451-5 | DOI Listing |
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