AI Article Synopsis
- Rheumatic paraneoplastic syndromes are uncommon but can indicate hidden cancers, often appearing within two years before a cancer diagnosis.
- An 18-year-old female with no prior health issues developed morning stiffness and a rash, leading to a diagnosis of systemic lupus erythematosus (SLE) and later the discovery of a dysgerminoma tumor.
- After surgery and chemotherapy for the tumor, her SLE symptoms went into remission, highlighting the need for doctors to consider cancer when patients show unexplained lupus symptoms.
Article Abstract
Rheumatic paraneoplastic syndromes are rare and generally occur no longer than two years before diagnosis of the associated malignancy. Therefore, it can be an essential clue to occult malignancy. A healthy 18-year-old female with no underlying diseases was referred to the rheumatology clinic due to morning stiffness in her hands and a new rash on her fingers. Her labs showed a positive ANA, anti-double strand DNA antibody, anti-RNP, and anti-ribosomal P. Nine months after the diagnosis with SLE, the patient presented with elevated levels of lactate dehydrogenase. A total-body computed tomography scan revealed a solid mass in the pelvis. The pathological findings corresponded to a dysgerminoma tumor. Following surgical tumor removal and chemotherapy, the patient went into remission with both SLE and her oncology conditions, with no relapse of her lupus symptoms in a one-year follow-up. This case underscores the importance of considering malignancy in unexplained lupus symptoms, a crucial point for all physicians to be aware of. We identified 13 cases of paraneoplastic SLE in a literature review. In most cases, SLE is resolved after the tumor has been treated.
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| http://dx.doi.org/10.1007/s11739-024-03790-6 | DOI Listing |
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