AI Article Synopsis
- Atherosclerosis (AS) is a major cause of cardiovascular and cerebrovascular diseases, and this research focuses on the role of lncRNA MBNL1-AS1 in AS patients compared to healthy controls.
- The study involved 103 AS patients and 92 healthy individuals, finding that MBNL1-AS1 levels were significantly higher in AS patients, correlated with increased carotid intima-media thickness (CIMT) and C-reactive protein (CRP) levels.
- MBNL1-AS1 shows promise as a diagnostic marker for AS, with a high accuracy rate, and its elevated levels are associated with a worse prognosis for patients, indicating a higher risk for cardiovascular events.
Article Abstract
Background: Atherosclerosis (AS) is the pathological basis of many cardiovascular and cerebrovascular diseases. To further the investigation of treatments for AS, this research analyzed the role of lncRNA MBNL1-AS1.
Methods: MBNL1-AS1 expression in the serum of AS patients and healthy controls were detected by qPCR. Its diagnostic value in AS was assessed by receiver operating characteristic curve (ROC). Additionally, the link between MBNL1-AS1, carotid intima-media thickness (CIMT) and C-reactive protein (CRP) was examined using the Spearman correlation coefficient. The prognostic value of MBNL1-AS1 in AS was assessed using the Kaplan-Meier survival curve and univariate and multivariate Cox regression analysis.
Results: The present study consisted of 103 patients with AS and 92 healthy patients (HC) and comparison of baseline data between the two groups revealed no remarkable difference (P>0.05) except for CRP (P<0.0001). The serum of AS patients exhibited a considerably higher expression of MBNL1-AS1 in comparison to the HC group. Furthermore, MBNL1-AS1 was highly expressed in patients following higher CIMT and CRP values, which was positively linked with both, respectively (r>0.5, P<0.001). Meanwhile. MBNL1-AS1 has enhanced diagnostic accuracy in AS patients (AUC=0.893) and can be utilized as an independent prognostic factor for AS. Patients with high MBNL1-AS1 expression have a higher likelihood of cardiovascular events. (log rang P=0.0025).
Conclusions: Elevated MBNL1-AS1p can be used as a potential marker for the clinical diagnosis of AS and is linked to a poor prognosis of AS.
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| http://dx.doi.org/10.23736/S2724-5683.24.06648-1 | DOI Listing |
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