AI Article Synopsis
- The study investigated macrolide resistance in 68 patients with complex pulmonary diseases, focusing on how treatment affected resistance profiles.
- Among patients not treated with macrolides, over half (52%) reverted to being susceptible to macrolides, while only a tiny fraction (2%) of those continuing treatment saw similar results.
- The analysis of 30 resistant isolates revealed that seven had shifted to susceptible profiles, with reasons including related strains or reinfections.
Article Abstract
This single-center retrospective study aimed to analyze the variability of macrolide resistance (MR) in 68 patients with complex pulmonary disease. Among 25 patients treated without macrolides, 13 (52%) reverted to macrolide-susceptible (MS) profiles. Only one (2%) of 43 patients who continued macrolide treatment showed this change. We compared 30 MR isolates with recent specimens. Among them, seven shifted to MS (five attributed to clonally related strains; two resulting from reinfection or polyclonal infection).
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539230 | PMC |
| http://dx.doi.org/10.1128/aac.01213-24 | DOI Listing |
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