AI Article Synopsis
- * This review focuses on how TGF-β interacts with monocytes and macrophages in the tumor microenvironment, impacting their activities and contributing to immunosuppression that aids tumor progression.
- * The article also highlights ongoing clinical efforts aimed at targeting TGF-β in cancer treatment, showing potential benefits in the field of immuno-oncology.
Article Abstract
TGF-β is a pivotal cytokine that orchestrates various aspects of cancer progression, including tumor growth, metastasis, and immune evasion. In this review, we present a comprehensive overview of the multifaceted role of transforming growth factor β (TGF-β) in cancer biology, focusing on its intricate interactions with monocytes and macrophages within the tumor microenvironment (TME). We specifically discuss how TGF-β modulates monocyte and macrophage activities, leading to immunosuppression and tumor progression. We conclude with the current translational and clinical efforts targeting TGF-β, recognizing the promising role of this strategy in immunooncology.
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| http://dx.doi.org/10.1080/08830185.2024.2411998 | DOI Listing |
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