AI Article Synopsis
- Alzheimer's disease is a major health issue due to its widespread occurrence and the limitations of existing treatments.
- Researchers studied a medicinal plant traditionally used for headaches to find compounds that might help combat Alzheimer's.
- They identified three specific compounds, with one showing the most promise by inhibiting key targets related to the disease, suggesting further development for potential Alzheimer's therapies.
Article Abstract
Alzheimer's disease is a significant concern due to its high prevalence and the limitations of current treatments. In our research, we investigated , a medicinal plant traditionally used for headaches, to identify active compounds with potential anti-Alzheimer's effects. Three pentacyclic triterpenes were isolated through column chromatography and characterised from the dichloromethane/methanol extract from (DCMEMf), with (3)-3-hydroxy-11-oxours-12-en-28-oic acid () showing the highest activity in the HMC3 and SVG p12 cell lines. Compound inhibited the pharmacological targets NF-κB, PGE2, IDO1, and EGFR with IC values of 9.83, 3.86, 1.63 μM, and 49.57 nM, respectively, attributed to a hydroxyl group at the C-3 position of its structure. These findings suggest the potential of these compounds in treating neurological diseases, including headaches, and offer promising prospects for the development of new therapies against Alzheimer's.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2024.2412839 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!