AI Article Synopsis
- Cardiovascular disease (CVD) is a significant global health issue, and understanding how it progresses is crucial for developing new treatments.* -
- Platelet-derived extracellular vesicles (PEVs) serve as potential diagnostic tools that reflect disease progression and may have protective effects against CVD.* -
- By studying PEVs more closely, researchers aim to improve their use as biomarkers and explore their potential in targeted therapies for CVD and cancer.*
Article Abstract
Purpose Of Review: Cardiovascular disease (CVD) remains a major global health burden. Rising incidences necessitate improved understanding of the pathophysiological processes underlying disease progression to foster the development of novel therapeutic strategies. Besides their well recognized role in CVD, platelet-derived extracellular vesicles (PEVs) mediate inter-organ cross talk and contribute to various inflammatory diseases.
Recent Findings: PEVs are readily accessible diagnostic biomarkers that mirror pathophysiological disease progression but also may confer cardioprotective properties. Monitoring the effects of modulation of PEV signatures through pharmacotherapies has also provided novel insights into treatment efficacy. Furthermore, exploiting their inherent ability to infiltrate thrombi, atherosclerotic plaques and solid tumours, PEVs as well as platelet-membrane coated nanoparticles are emerging as novel effective and targeted treatment options for CVD and cancer.
Summary: Collectively, in-depth characterization of PEVs in various diseases ultimately enhances their use as diagnostic or prognostic biomarkers and potential therapeutic targets, making them clinically relevant candidates to positively impact patient outcomes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620325 | PMC |
| http://dx.doi.org/10.1097/MOH.0000000000000845 | DOI Listing |
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