AI Article Synopsis
- A study was conducted in Denmark to assess the awareness of the teratogenic risks associated with oral retinoids and the adherence to pregnancy prevention programs (PPP) among healthcare providers and patients.
- Surveys were distributed to dermatologists, general practitioners, pharmacists, and women of childbearing age using oral retinoids, revealing high awareness levels of teratogenicity (95-100%) across the groups.
- Despite this awareness, there was inconsistent adherence to PPP measures, indicating a need for improved accessibility and encouragement of certain safety practices, especially those requiring patient signatures.
Article Abstract
Purpose: We aimed to investigate the awareness of oral retinoid teratogenicity and the adherence to the pregnancy prevention program (PPP) related to oral retinoid use by physicians, pharmacists, and patients in Denmark.
Methods: As part of the multi-country survey, web-based questionnaires were distributed among Danish dermatologists, general practitioners, community pharmacists, and women of childbearing age, who were using or had used oral retinoids within the past 5 years.
Results: A total of 62 physicians, 96 pharmacists, and 50 oral retinoid using women responded; 95%, 100%, and 98%, respectively, were aware of the teratogenic risks of oral retinoids. For physicians, the most applied PPP measures were the usage of the patient (44%) and the healthcare professional (19%) guides, while the least applied measure was signing medication risk awareness form (3%). Among the pharmacists, the warning sign on the outer medication package was the most used measure (45%). Among the women, a majority (90%) had read the patient information leaflet included in the medication package and 72% discussed the use of contraception with their healthcare provider, while risk awareness forms and patient cards were seen by only few.
Conclusions: In Denmark, physicians, pharmacists, and medicine users were aware about the teratogenic effects of oral retinoids. Adherence to pregnancy prevention measures varied, suggesting unwillingness to use the measures that require patients' signatures among physicians and a lack of awareness of pharmacy targeting measures. Accessibility of the latter measures need to be optimized to improve the safety of oral retinoid use.
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| http://dx.doi.org/10.1002/pds.70023 | DOI Listing |
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