We present the case of a newborn female that was referred for review of a large melanocytic lesion on the lower back and multiple smaller lesions. Two biopsies were taken which showed features of congenital naevus and a small component of spindled dendritic cells that showed no positivity with melanocytic markers. As such, the histopathological findings of these biopsies were consistent with a diagnosis of a congenital naevus with areas resembling a neurocristic hamartoma. This case serves to highlight this rare condition and its clinical presentation, histopathological features and the importance of its early diagnosis and surveillance.
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http://dx.doi.org/10.1093/ced/llae408 | DOI Listing |
J Med Case Rep
December 2024
Department of Surgery, Aga Khan University, Karachi, Pakistan.
Background: Kaposiform hemangioendothelioma is a rare vascular tumor primarily occurring in infants and children. The most common sites for kaposiform hemangioendothelioma are extremities, with very few cases of abdominal kaposiform hemangioendothelioma reported in neonates. Making a diagnosis of Kaposiform hemangioendothelioma can be challenging when the patient presents with generalized symptoms such as bilious vomiting and constipation that can be attributed to other more common causes of intestinal obstruction.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
December 2024
Department of Paediatrics & Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Background: Adverse birth outcomes (preterm birth, low birth weight, small for gestational age, and stillbirth) seem to persist in infants born to people with HIV, even in the context of maternal antiretroviral therapy. However, findings have been disparate, inconclusive, and difficult to compare directly across settings, partly owing to variable outcome definitions. We aimed to collate, compare, and map existing adverse birth outcome definitions to inform a harmonized approach to universally measure these outcomes in studies including pregnant people with HIV.
View Article and Find Full Text PDFChilds Nerv Syst
December 2024
Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
Extraventricular neurocytoma (EVN) is a rare neuronal tumor with a marked tendency towards ganglionic or glial differentiation. Although EVN commonly occurs in young adults, congenital cases are extremely rare, and standardized therapeutic strategies remain undetermined. The presence of atypical features such as increased mitotic activity on histological analysis is correlated with a higher rate of recurrence and poor prognosis.
View Article and Find Full Text PDFIndian J Pediatr
December 2024
Department of Pediatrics, WHO Collaborating Center for Newborn Care and Research, All India Institute of Medical Sciences, New Delhi, 110 029, India.
Objectives: Comprehensive packages for training healthcare professionals who care for premature newborns are scarce. AIIMS WHO CC, New Delhi, partnered with India Association of Neonatal Nurses (IANN) and National Neonatology Forum (NNF) and 35 national leaders in the field of newborn care to develop a multimodal educational package for preterm infants.
Methods: Findings from evaluation of four representative special newborn care units in the state of Madhya Pradesh informed the content of the package.
Health Technol Assess
December 2024
Usher Institute, University of Edinburgh, Edinburgh, UK.
Background: Around one in three pregnant women undergoes induction of labour in the United Kingdom, usually preceded by in-hospital cervical ripening to soften and open the cervix.
Objectives: This study set out to determine whether cervical ripening at home is within an acceptable safety margin of cervical ripening in hospital, is effective, acceptable and cost-effective from both National Health Service and service user perspectives.
Design: The CHOICE study comprised a prospective multicentre observational cohort study using routinely collected data (CHOICE cohort), a process evaluation comprising a survey and nested case studies (qCHOICE) and a cost-effectiveness analysis.
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