AI Article Synopsis
- The study examines the biocompatibility and osteoinductive properties of bioactive ceramics made from single-phase hydroxyapatite (HAP) and two-phase HAP with β-TCP, focusing on various chemical modifications.
- The results show that treatments improved the ceramics' solubility, increased porosity, and enhanced adsorption activity, leading to favorable conditions for cell adhesion and survival in culture.
- Calcium phosphate ceramics were found to stimulate important cellular processes, suggesting these HAP-based bioceramics could be effective for bone regeneration and reconstruction.
Article Abstract
Objective: In this study we have focused on biocompatibility and osteoinductive capacity analysis of self-manufactured single-phase (HAP) and two-phase (HAP and β-ТСР) bioactive ceramics with various chemical modifications (Fig. 1).
Results: We demonstrate a reduction in solubility for all analyzed composite after the treatment with HO and HO, accompanied by an enhancement in adsorption activity. This modification also resulted in an increase in micro- and macroporosity, along with a rise in the open porosity. Adipose-derived mesenchymal stromal cells demonstrated excellent cell adhesion and survival when cultured with these ceramics. Calcium phosphate ceramics (H-500, HT-500, and HT-1 series) stimulated alkaline phosphatase expression, promoted calcium deposition, and enhanced osteopontin expression in ADSCs, independently inducing osteogenesis without additional osteogenic stimuli. These findings underscore the promising potential of HAP-based bioceramics for bone regeneration/reconstruction.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460134 | PMC |
| http://dx.doi.org/10.1186/s13104-024-06937-y | DOI Listing |
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