Since 2003, FEBS Letters has awarded an annual prize to the corresponding author of the best research paper published in the journal in the previous calendar year. The award-winning article is selected by a special committee formed by appointed members of the Editorial Board, plus one external member. The winner of the 2024 FEBS Letters Award is Professor Rachel Flynn of Boston University Chobanian & Avedisian School of Medicine, for the outstanding paper "The exoribonuclease XRN2 mediates degradation of the long non-coding telomeric RNA TERRA." In this interview, Rachel Flynn talks about her award-winning research.
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http://dx.doi.org/10.1002/1873-3468.15031 | DOI Listing |
FEBS Lett
January 2025
Department of Symbiotic Science of Environment and Natural Resources, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Japan.
Carbonyl sulfide hydrolase (COSase) is a unique enzyme that exhibits high activity towards carbonyl sulfide (COS) but low carbonic anhydrase (CA) activity, despite belonging to the CA family. COSase was initially identified in a sulfur-oxidizing bacterium and later discovered in the ascomycete Trichoderma harzianum strain THIF08. The COSase from T.
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January 2025
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Soluble, circulating Klotho (sKlotho) is essential for normal health and renal function. sKlotho is shed from the renal distal convoluted tubule (DCT), its primary source, via enzymatic cleavage. However, the physiologic mechanisms that control sKlotho production, trafficking, and shedding are not fully defined.
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January 2025
Department of Biomedical Sciences, Creighton University, Omaha, NE, USA.
Protein-protein interactions involving 14-3-3 proteins regulate various cellular activities in normal and pathological conditions. These interactions have mostly been reported to be phosphorylation-dependent, but the 14-3-3 proteins also interact with unphosphorylated proteins. In this work, we investigated whether phosphorylation is required, or, alternatively, whether negative charges are sufficient for 14-3-3ε binding.
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January 2025
Institute of Pharmaceutical Science, King's College London, UK.
FEBS Lett
January 2025
Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, CA, USA.
Lipid nanodiscs have become a widely used approach for studying membrane proteins thanks to several advantages they offer. They have been especially useful for studying ABC transporters, despite the growing concern about the possible restriction of the conformational changes of the transporters due to the small size of the discs. Here, we performed a systematic study to determine the effect of the nanodisc size on the ATPase activity of model ABC transporters from human, plant, and bacteria.
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