Coexisting invasive ductal carcinoma arising within a benign phyllodes tumour.

BMJ Case Rep

Medway NHS Foundation Trust, Gillingham, Medway, UK.

Published: October 2024

AI Article Synopsis

  • A woman in her 40s with a 2-year history of a growing lump in her right breast was examined and found to have a significant mass, leading to MRI and biopsy evaluations.
  • The diagnosis confirmed a benign phyllodes tumor, but also identified an incidental invasive ductal carcinoma and high-grade ductal carcinoma in situ within the excised tissue.
  • After surgery and further treatments including radiotherapy and chemotherapy, the patient has remained disease-free for 20 months, highlighting the need for careful examination of phyllodes tumors to detect any malignant features.

Article Abstract

A woman in her 40s presented to the breast clinic with a 2-year history of an enlarging right breast lump. Examination revealed a 10 cm firm mass in the upper outer quadrant of the right breast. MRI and ultrasonography results revealed an 8 cm mass in the right breast and suspicious axillary nodes. Biopsy results of this mass revealed a sclerosed fibroadenoma (B2). Excision of the right breast lump had shown a benign phyllodes tumour, containing an incidental invasive ductal carcinoma and high-grade ductal carcinoma in situ. The patient underwent a right breast cavitectomy and sentinel lymph node biopsy, which revealed no further disease. She received adjuvant radiotherapy, chemotherapy and anti-HER2 treatment, and has remained disease-free at 20-month follow-up. The coexistence of an invasive carcinoma arising within a benign phyllodes tumour is rare. This case report underscores the importance of thoroughly examining excised specimens for phyllodes tumour to exclude malignant components.

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Source
http://dx.doi.org/10.1136/bcr-2024-262414DOI Listing

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