AI Article Synopsis

  • The study investigates how mandibular advancement affects gene expression in young rats' mandibular condylar cartilage, focusing on Sdf1 and Foxc1 during a recovery phase.
  • Four groups of Wistar rats were used, including a control and experimental group, with methods involving real-time RT-PCR and histological analysis to assess changes during and after the use of the dental appliance.
  • Results showed significant changes in genetic expression and cartilage layers, indicating that the mandibular advancement appliances stimulate growth in the cartilage, with persistent changes in gene expression even after removal of the appliances.

Article Abstract

Purpose: This study evaluated the impact of mandibular advancement on Sdf1 and Foxc1 gene expression in the mandibular condylar cartilage of young Wistar rats. By examining the changes that occur during a unique one-month recovery period, it highlights the critical role of gene expression and condylar adaptation during the recovery phase. The analysis focused on whether, during the recovery period, reversal changes occur when functional appliances are removed and whether genetic expression important for condyle growth and adaptation downregulates.

Material And Methods: The study involved 30 male Wistar rats divided into 2 control groups Appliance Control and Recovery Control groups, and 2 experimental groups, the Appliance group with mandibular advancement bite-jumping appliance for 30 days, and the Recovery group with appliance for 30 days followed by a 30-day recovery. Molecular analysis of condylar cartilage using real-time RT-PCR and histological assessments was conducted.

Results: Significant genetic expression alterations were noted in both the experimental groups for Sdf1 (p < 0.05) and Foxc1 (p < 0.05). According to histological investigations, significant alterations with an increase in the proliferative and hypertrophic layer in condylar cartilage were seen.

Conclusion: Mandibular advancement bite-jumping appliances induce proliferative and hypertrophic layer changes in mandibular condylar cartilage, shown by elevated Foxc1 levels and decreased Sdf1 levels. Post-appliance removal, persistent gene expression reveals a true joint stimulation.

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Source
http://dx.doi.org/10.1016/j.jormas.2024.102109DOI Listing

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