Is zirconia surface etching a viable alternative to airborne particle abrasion? A systematic review and meta-analysis of in vitro studies.

Objectives: This systematic review aimed to determine the effectiveness of various etching surface treatments on zirconia bond strength with the following research question: "Can zirconia etching serve as a viable alternative to airborne particle abrasion (APA) for achieving reliable bonding?".

Data: In vitro studies comparing APA, performed with either conventional or silica-coated aluminum oxide (AlO) particles, with various etching protocols in terms of bonding performance were included. The risk of bias of the included studies was assessed using the QUIN's tool for in vitro studies. Meta-analyses were performed using RevMan; random-effects models were applied, and heterogeneity was tested using the I index. The significance level was set at p < 0.05.

Sources: A comprehensive literature search was conducted across electronic databases, including Clarivate Analytics' Web of Science, Cochrane Library, EMBASE, PubMed, Scopus and ProQuest.

Study Selection: Fifty-four relevant articles were included in this systematic review. According to the QUIN's tool, 7 studies were rated as "high risk of bias", 46 studies were rated as "medium risk", and 1 study was rated as "low risk". Nineteen studies were used for meta-analyses. Mostly, APA demonstrated significantly higher bond strength compared to various etching protocols (p < 0.05). However, no statistical difference was found between APA and high concentrations (40-48 %) of hydrofluoric acid (HF) in terms of immediate- and medium-term bond strength to resin composite (p > 0.05). On enamel, an experimental hot etching solution performed significantly better than APA in short-term follow-up (p < 0.05). A novel multi-acid solution exhibited significantly higher immediate shear bond strength to resin cement than APA (p < 0.05). Variable heterogeneity, ranging from low to high, was observed.

Conclusions: APA remains the surface treatment with the strongest evidence in the literature and it is usually more efficacious than zirconia etching. However, highly concentrated HF and an experimental hot etching solution have demonstrated similar or significantly higher bond strength values over time compared to APA, depending on the adhesive substrate. A recently introduced multi-acid solution (Zircos-E) needs to be further explored, especially in regards to long-term bond durability.

Clinical Significance: This systematic review provides a comprehensive analysis of the existing in vitro evidence on the potential of zirconia etching and the bond durability of resin-based materials after artificial aging. Selecting appropriate surface treatment protocols is crucial for achieving optimal clinical outcomes.