AI Article Synopsis
- Hypertension and chronic kidney disease (CKD) are interconnected, with high blood pressure worsening kidney health and vice versa, creating a cycle of deteriorating health.
- Managing hypertension in CKD patients is critical as it not only helps preserve kidney function but also reduces cardiovascular risks, which are the leading causes of death in these individuals.
- New treatment options are emerging for CKD that specifically target the interactions between hypertension and kidney disease, potentially transforming how high blood pressure is managed in these patients.
Article Abstract
Background: Hypertension and chronic kidney disease (CKD) are closely interlinked pathophysiologic states, such that high blood pressure (BP) is an independent risk factor for disease progression in both adult and pediatric patients with kidney disorders and progressive decline in kidney function can conversely lead to worsening BP control.
Summary: Hypertension in CKD is not only associated with GFR loss, but increases cardiovascular risk, which is the leading source of mortality and morbidity in this population. Given this complex relationship between hypertension, CKD, and CVD, an optimal management of BP in CKD is mandatory to break an established vicious pathophysiological cycle that leads to adverse outcomes.
Key Messages: New promising molecules for the treatment of CKD, with interesting mechanisms, particularly regarding their pathophysiological interactions with arterial hypertension, are available or under development and in the very next future they may change the way we treat high BP in CKD patients.
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| http://dx.doi.org/10.1159/000541876 | DOI Listing |
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