Latino patients with dementia face a complex web of challenges, from serious comorbidities to delayed diagnoses to fragmented care.
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HIV Vulnerability Typologies Among Adolescent Girls and Young Women in Lesotho: A Population-Based, Cross-Sectional, Latent Class Analysis.
J Assoc Nurses AIDS Care
January 2025
Cho-Hee Shrader, PhD, MPH, is a Postdoctoral Research Scholar and MS Nursing Student, Arizona State University, College of Nursing and Health Innovation, Phoenix, Arizona, USA.
Adolescent girls and young women ages 15-29 years (AGYW) living in Lesotho experience a disproportionate HIV burden. Using a household-based national survey in Lesotho, we conducted a three-step latent class analysis to identify typologies of AGYW most vulnerable to HIV infection. We first classified AGYW into HIV vulnerability groups based on self-reported sexual behaviors, then identified associations between typology and HIV diagnosis.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Background: Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD) and disproportionately impacts under-represented groups including Mexican Americans/Hispanics (MAs) and African Americans/Blacks (AAs) compared to non-Hispanic Whites (NHWs). However, it remains unclear how amyloid, tau, and neurodegeneration (AT(N)) AD imaging biomarkers and cognitive functioning differ across diabetic stages including non-diabetes, pre-diabetes, and T2DM in a diverse community-based cohort.
Method: Data were obtained from the well-characterized Health and Aging Brain Study: Health Disparities (HABS-HD) cohort, including MAs (n=612), AAs (n=676), and NHWs (n=725) with clinical, amyloid and tau positron emission tomography (PET), and cortical thickness measures from magnetic resonance imaging (MRI) scans.
Biomarkers.
Alzheimers Dement
December 2024
Memory and Aging Center, UCSF Weill Institute for Neurosciences, San Francisco, CA, USA.
Background: Early onset dementia (EOD) affects people at the peak of their personal and professional responsibilities and economic productivity. Alzheimer's disease (AD) and Frontotemporal Dementia (FTD) are the most common EOD etiologies in Non-Latinx White adults (NLW). Black and Latinx older adults bear a disproportionate burden of dementia compared to NLW, likely due to vulnerabilities that confer increased risk, such as cardiovascular factors, socioeconomic stressors, and structural racism.
View Article and Find Full Text PDFBackground: Efforts to increase heterogeneity in cohorts of cognitively normal older adults with Alzheimer's disease (AD) neuroimaging biomarkers have resulted in large datasets with differing characteristics. It is unclear whether associations between AD biomarkers and key demographic and genetic factors are generalizable across heterogeneous cohorts.
Method: PET and MR scans from cognitively normal older adults aged >55 in the Berkeley Aging Cohort Study (BACS), ADNI, the Health and Aging Brain Study-Health Disparities (HABS-HD) and POINTER Imaging were processed using harmonized pipelines.
Background: Alzheimer's disease and related dementias (ADRD) place enormous burdens on families, care partners, and the public programs that finance ADRD services. Caregiving is disproportionately provided by women, individuals of low socioeconomic status, and underserved minority populations, who also rely upon informal care and support. National dementia strategies rarely address the needs of care partners.
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