AI Article Synopsis
- CSF1R-related leukoencephalopathy is an autosomal dominant leukodystrophy linked to mutations in the CSF1R gene, and shows different brain changes compared to subcortical ischemic vascular dementia (SIVaD), which is related to small vessel disease.
- In a study, researchers compared white matter hyperintensity (WMH) patterns and cortical thickness in 14 patients with CSF1R-related leukoencephalopathy and 129 with SIVaD, using advanced imaging techniques.
- Results indicated that CSF1R-related leukoencephalopathy had more severe corpus callosum atrophy and cortical thinning, with WMH mainly in the frontal and parietal
Article Abstract
Background: CSF1R-related leukoencephalopathy is a type of autosomal dominant leukodystrophy caused by mutations in the colony stimulating factor 1 receptor (CSF1R) gene. Subcortical ischemic vascular dementia (SIVaD), which is caused by cerebral small vessel disease, is similar to CSF1R-related leukoencephalopathy in that it mainly affects subcortical white matter. In this study, we compared the patterns of white matter hyperintensity (WMH) and cortical thickness in CSF1R-related leukoencephalopathy with those in SIVaD.
Methods: Fourteen patients with CSF1R-related leukoencephalopathy and 129 with SIVaD were retrospectively recruited from three tertiary medical centers. We extracted and visualized WMH data using voxel-based morphometry to compare the WMH distributions between the two groups. Cortical thickness was measured using a surface-based method. Statistical maps of differences in cortical thickness between the two groups were generated using a surface model, with age, sex, education, and intracranial volume as covariates.
Results: Predominant distribution of WMH in the CSF1R-related leukoencephalopathy group was in the bilateral frontal and parietal areas, whereas the SIVaD group showed diffuse WMH involvement in the bilateral frontal, parietal, and temporal areas. Compared with the SIVaD group, the CSF1R-related leukoencephalopathy group showed more severe corpus callosum atrophy (CCA) and widespread cortical thinning.
Conclusions: To our knowledge, this is the first study using the automated MR measurement to capture WMH, cortical thinning, and CCA with signal changes in CSF1R-related leukoencephalopathy. It provides new evidence regarding differences in the patterns of WMH distribution and cortical thinning between CSF1R-related leukoencephalopathy and SIVaD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458039 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0308989 | PLOS |
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