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Introduction: The aim of our study was to assess the outcome of Gore-Tex sutures in minimally invasive scleral fixation of subluxated posterior chamber intraocular lenses (PCIOLs) and to demonstrate a method for validating the lens position.
Methods: Retrospective study of patients who underwent lasso in-the-bag scleral fixation of a subluxated PCIOL using the snare technique with Gore-Tex suture from 2019 to 2021 in a single tertiary medical center. Functional outcome was analyzed by clinical assessment, and anatomical outcome, by ultrasound biomicroscopy (UBM).
Preclinical evaluation of NG101, a potential AAV gene therapy for wet age-related macular degeneration.
Mol Ther Methods Clin Dev
December 2024
Neuracle Genetics Inc., Seoul 02841, Republic of Korea.
Article Synopsis
- - Age-related macular degeneration (AMD) is a major cause of vision loss in people over 55, and about 10%-15% of patients develop a severe form called wet AMD (wAMD), which leads to almost 90% of AMD-related blindness.
- - The standard treatment for wAMD involves frequent injections to inhibit a protein called VEGF, creating a need for options that require less frequent administration.
- - New findings show that a single injection of NG101, a gene therapy delivering aflibercept (an anti-VEGF agent), effectively reduces damage from wet AMD with lasting effects in animal studies, suggesting it could be an effective and convenient treatment alternative.
Insights Into Cataract Surgery Outcomes In Age-Related Macular Degeneration: Real-World Perspectives Across Severity Grades.
Ophthalmol Retina
November 2024
Department of Ophthalmology, Charité University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health; Berlin Institute of Health (BIH), Berlin, Germany. Electronic address:
Purpose: Cataract and age-related macular degeneration (AMD) share age as a main risk factor and thus have a high coincidence. Both conditions substantially reduce visual acuity. This study aimed to assess the impact of cataract surgery on visual acuity, retinal morphology, and vascular-endothelial-growth-factor (VEGF) inhibitor therapy in patients with AMD.
View Article and Find Full Text PDFPooled Multicenter Safety Analysis of Lupin's Intravitreal Biosimilar Ranibizumab (Ranieyes) in Chorioretinal Vascular Diseases.
Ophthalmol Ther
November 2024
Disha Eye Hospitals, 88 Ghoshpara Road, Barrackpore, Kolkata, West Bengal, 700120, India.
Introduction: This study aims to evaluate the ocular and systemic safety profiles of intravitreal biosimilar ranibizumab Ranieyes (Lupin Pharmaceuticals, Mumbai, India) in real-world clinical settings across multiple chorioretinal vascular diseases, including neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO) in adults.
Methods: We conducted a retrospective, consecutive, interventional, uncontrolled multicenter study using data from three hospital networks in India. A total of 1401 eyes received 2194 injections of Ranieyes between June 2022 and November 2023.
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