Integrating ethics in public health guideline development: a case-study of the NTCA guidelines on respiratory isolation for persons with TB in community settings.

Public health interventions often involve explicit tradeoffs in which the health of the many must be weighed against burdens imposed on individuals. We describe development of public health guidelines for respiratory isolation in community settings for persons with tuberculosis. While stopping the spread of disease is a core moral imperative in public health, the duty to prevent disease transmission does not supersede all other considerations. Community wellbeing must be balanced with individual wellbeing, liberty, and social justice. In response to these challenges, the National TB Coalition of America's (NTCA) 2024 Guidelines for persons with tuberculosis in community settings were developed using a modified GRADE approach supported by a complementary, comprehensive, and context-specific ethical framework. By addressing the distinct roles that evidence (subject to uncertainty), values, justificatory conditions, and procedural legitimacy all play in ethical guideline development, we promote rigor and transparency in the integration of ethics in public health guidelines.