AI Article Synopsis

  • A 68-year-old woman presented with low back pain for two months, leading to imaging that indicated possible bone metastases due to hyperintense lesions in the lumbar region.
  • Further imaging revealed both osteolytic and mixed osteolytic-osteoblastic lesions with varying degrees of F-FDG uptake, but no primary tumor could be identified.
  • Ultimately, the patient was diagnosed with low-grade myofibroblastic sarcoma after biopsy and surgery, highlighting that this rare condition should be considered when diagnosing multiple bone metastases.

Article Abstract

A 68-year-old woman with low back pain for 2 months was admitted. T2-weighted fat-saturated imaging revealed hyperintense lesions in multiple lumbar regions, suggesting the possibility of bone metastases. Multiple osteolytic and mixed osteolytic-osteoblastic lesions with significant F-fluorodeoxyglucose (F-FDG) uptake, as well as multiple osteoblastic lesions with mild F-FDG uptake, were observed on subsequent F-FDG positron emission tomography/computed tomography without an identifiable primary lesion. This patient was pathologically diagnosed with low-grade myofibroblastic sarcoma (LGMS) after biopsy and surgery. Although multiple bone involvement in LGMS is extremely rare, this case suggests that it should be considered in the differential diagnosis of multiple bone metastases.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589350PMC
http://dx.doi.org/10.4274/mirt.galenos.2024.14238DOI Listing

Publication Analysis

Top Keywords

multiple bone
12
bone involvement
8
low-grade myofibroblastic
8
myofibroblastic sarcoma
8
bone metastases
8
f-fdg uptake
8
multiple
6
involvement low-grade
4
sarcoma demonstrated
4
f-fdg
4

Similar Publications

CD4 T Cells Mediate Dendritic Cell Licensing to Promote Multi-Antigen Anti-Leukemic Immune Response.

Cancer Med

January 2025

Division of Oncology, The Children's Hospitial of Philadelphia, Philadelphia, Pennsylvania, USA.

Background: Single antigen (Ag)-targeted immunotherapies for acute lymphoblastic leukemia (ALL) are highly effective; however, up to 50% of patients relapse after these treatments. Most of these relapses lack target Ag expression, suggesting targeting multiple Ags would be advantageous.

Materials & Methods: The multi-Ag immune responses to ALL induced by transducing cell lines with xenoAgs green fluorescent protein and firefly luciferase was elucidated using flow cytometry, ELISA, and ELISpot assays.

View Article and Find Full Text PDF

Association of trabecular bone score corrected for tissue thickness with glucose metabolism in acromegaly.

Front Endocrinol (Lausanne)

December 2024

5th Department of Internal Medicine, Comenius University Faculty of Medicine, University Hospital Bratislava, Bratislava, Slovakia.

Introduction: Acromegaly is associated with increased vertebral fracture (VF) risk regardless of bone mineral density (BMD). However, the vertebral trabecular compartment is still low; a possible contributor to this may be impaired glucose metabolism (GM) which frequently complicates acromegaly. Additionally, soft tissue thickness may confound bone imaging in acromegaly patients.

View Article and Find Full Text PDF

Background: Bone metastases are complications of many cancers, including colon cancer. Whole body bone scan is commonly used to detect bone metastases in these patients. Bone scan findings are sensitive for detecting metastases but with less experience and especially without the use of single photon emission computed tomography/computed tomography (SPECT/CT) images, they are less specific.

View Article and Find Full Text PDF

Background: While the surgical treatment of mandibular stage 3 medication-related osteonecrosis of the jaw (MRONJ) is well-documented, research on maxillary stage 3 MRONJ is limited. Antiresorptive medications can induce MRONJ and atypical femoral fracture (AFF), but their impact on the feasibility of using fibula flaps for reconstruction remains controversial. This study aimed to assess the surgical outcomes and functional recovery of fibula flap reconstruction for maxillary stage 3 MRONJ, considering both recipient and donor site outcomes.

View Article and Find Full Text PDF

Acetabular osteophyte formation in dysplastic hip osteoarthritis.

BMC Musculoskelet Disord

December 2024

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, 8 Showa-ku, Nagoya, Japan.

The growth of periacetabular osteophytes with developmental dysplasia of the hip (DDH) remains unclear. This study aimed to perform a three-dimensional assessment of periacetabular osteophytes and the effects of superiorization (SP) and lateralization (LT) of the femoral head on osteophyte formation. Female (n = 105) with unilateral hip osteoarthritis due to DDH who underwent total hip arthroplasty between 2016 and 2022 were included.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!