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| http://dx.doi.org/10.33393/aop.2024.3293 | DOI Listing |
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Radiation therapy for childhood-onset craniopharyngioma: systematic review and meta-analysis.
J Neurooncol
January 2025
Department of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, 100045, China.
Background: Craniopharyngioma (CP), a benign tumor originating from remnants of Rathke's pouch in the sellar region, accounts for approximately 30% of all cases of craniopharyngioma. Radiation therapy has been used to treat CP patients for decades; however, there is still a lack of systematic reviews on the long-term tumor control outcomes in pediatric CP patients treated with external radiation therapy.
Methods: We conducted a comprehensive search of multiple databases for studies on the tumor progression rates of childhood-onset CP(COCP) patients who received external radiotherapy.
Improvement of beam type element models of welded tubular junctions for fatigue analysis using artificial neural networks.
Heliyon
November 2024
Department of Industrial Engineering and Automotive, Nebrija University, Santa Cruz de Marcendo 27, 28040, Madrid, Spain.
The use of numerical methods for structural analysis has been increasingly integrated within the design process in different engineering fields over the last decades, inasmuch as the capacity of the computing resources have growth. This gave rise to calculation techniques based on virtual models such as the finite element method, which is nowadays a reference method for evaluation of complex tubular structures with vast application in the industry. For such type of structures, modeling approaches based on beam type elements are usually employed since they provide simplicity and low computational costs.
View Article and Find Full Text PDFEvolution of endometrial cancer incidence patterns in Hong Kong: A three-decade analysis with future projections.
Heliyon
November 2024
Third Department of Medical Oncology, Shaanxi Provincial Cancer Hospital Affiliated to Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Objective: This study provides a comprehensive analysis of endometrial cancer incidence trends in Hong Kong over the past three decades. It aims to evaluate the impact of demographic shifts and epidemiological factors, including age, birth cohort, and diagnosis period, on the incidence rates. The study also projects future trends in endometrial cancer cases up to 2030 and assesses the contributions of these factors using a detailed decomposition approach.
View Article and Find Full Text PDFEmerging Alzheimer's disease treatment paradigms: A late-stage clinical trial review.
Alzheimers Dement (N Y)
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Introduction: Without disease-modifying interventions, Medicare and Medicaid spending on Alzheimer's disease (AD) management is expected to reach 637 billion USD annually by 2050. The recent advent of promising AD therapies after decades of a near-total failure rate in clinical trials suggests that more disease-modifying therapies are on the horizon. In this review, we assess the late-stage pipeline of disease-modifying candidates for AD and offer a novel classification of intervention candidates by treatment paradigms-groups of candidates that share an underlying biological mechanism of action and general disease target.
View Article and Find Full Text PDFThe evolution of health policy and systems research in 11 low- and middle-income countries and the role of the Alliance for Health Policy and Systems Research: a bibliometric analysis for 1999-2020.
Health Res Policy Syst
January 2025
Center on Commercial Determinants of Health and Department of Global Health, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States of America.
Objectives: Given the rapid growth of the field of health policy and systems research (HPSR), it is important to monitor the research environment, especially the evolution of HPSR research outputs in low- and middle-income countries (LMICs). The objective of this study was to generate quantitative metrics to assess the production of HPSR publications and the role of the Alliance for Health Policy and Systems Research (the Alliance) grant-funded projects in 11 LMICs over the past 20 years.
Methods: We conducted a systematic literature search for HPSR literature from 1999 to 2020 pertaining to 11 target LMIC countries, including grey literature.
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