A Rare Case of Tirzepatide-Induced Hepatotoxicity.

ACG Case Rep J

Department of Hepatology, Liver Institute Northwest, Seattle, WA.

Published: October 2024

AI Article Synopsis

  • Tirzepatide is the first dual incretin receptor activator approved for treating type II diabetes and obesity.
  • It has shown benefits in reducing liver fat without known cases of liver damage from its use.
  • However, a case of elevated liver enzymes was reported in a 37-year-old woman with metabolic syndrome after using tirzepatide.

Article Abstract

Tirzepatide is the first dual incretin glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor activator approved for the management of type II diabetes mellitus. This drug was also recently approved by the Food and Drug Administration as a management option for patients with obesity. Tirzepatide has been also reported to be beneficial in reducing liver fat content. Although its efficacy is well described in the literature, no cases of tirzepatide-induced hepatotoxicity have been reported. We report a case of a 37-year-old woman with metabolic syndrome who was noted to have elevated liver enzymes secondary to tirzepatide use.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452087PMC
http://dx.doi.org/10.14309/crj.0000000000001484DOI Listing

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Article Synopsis
  • Tirzepatide is the first dual incretin receptor activator approved for treating type II diabetes and obesity.
  • It has shown benefits in reducing liver fat without known cases of liver damage from its use.
  • However, a case of elevated liver enzymes was reported in a 37-year-old woman with metabolic syndrome after using tirzepatide.
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