AI Article Synopsis
- RET fusions are linked to non-small cell lung cancer (NSCLC), and while RET-targeted treatments like Prasetinib have been effective, patients can develop resistance, limiting their options.
- A case study highlights a patient with advanced lung adenocarcinoma and RET fusion who initially responded well to Prasetinib but later faced malignant pleural effusion after 24 months.
- The patient received a combination of intrapleural and systemic Tislelizumab injections with chemotherapy, leading to significant clinical improvement and control of pleural effusion for over six months, suggesting intrapleural immunotherapy as a promising option for treatment-resistant cases.
Article Abstract
RET fusions were discovered in non-small cell lung cancer (NSCLC), and the efficacy of RET-targeted treatment in these patients has been previously established. However, patients with required resistance to RET-TKIs have limited treatment options. Herein, we describe a case of critical and advanced lung adenocarcinoma harboring RET fusion. Despite a significant response to Prasetinib previously, the patient developed refractory malignant pleural effusion after 24 months of treatment. He was treated simultaneously with intrapleural plus systemic Tislelizumab injection combined chemotherapy, thereby achieving an excellent clinical benefit maintaining control of pleural effusion for over 6 months. Hence, we would like to discuss intrapleural immunotherapy as an additional treatment method in refractory malignant pleural effusion while demonstrating good treatment tolerance.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449677 | PMC |
| http://dx.doi.org/10.3389/fonc.2024.1404173 | DOI Listing |
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