Immune-Mediated Glomerulonephritis as Type 2 Lepra Reaction Posttreatment of Lepromatous Leprosy: A Case Report.

Indian J Nephrol

Department of Medicine, The Grant Government Medical College and Sir J.J. Group of Hospitals, JJ Marg, Nagpada-Mumbai Central, Near Sandhurst Road and J J Police Station, Mumbai, Maharashtra, India.

Published: June 2024

AI Article Synopsis

  • - A 57-year-old man experienced acute glomerulonephritis after receiving treatment for leprosy, which caused issues with his skin and nerves.
  • - His clinical examination showed new swelling in the legs and ongoing nerve and skin problems, while lab tests indicated high serum creatinine and low complement levels.
  • - A renal biopsy confirmed immune complex deposition linked to leprosy, and treatment with oral steroids successfully resolved his kidney condition.

Article Abstract

Leprosy, an infectious disease known for its debilitating effects on the skin and nerves, can trigger immunologic reactions affecting multiple organs. We present the case of a 57-year-old male who developed acute glomerulonephritis following leprosy treatment. Clinical examination revealed newly developed pitting edema in the legs, along with residual nerve thickening and skin changes. Laboratory findings showed elevated serum creatinine (3.2mg/dl) accompanied by low C3 and C4 levels. Urinalysis supported the diagnosis of glomerulonephritis. Renal biopsy demonstrated immune complex deposition on immunofluorescence, suggesting a diagnosis of leprosy-related post-treatment immune-mediated glomerulonephritis. Treatment with oral steroids led to complete resolution of the condition.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450797PMC
http://dx.doi.org/10.25259/ijn_536_23DOI Listing

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