Prolonged storage of sera at -20 degrees C did not significantly affect anti-Candida precipitin titers measured by counterimmunoelectrophoresis when compared with the original determinations.
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http://dx.doi.org/10.1128/jcm.10.4.593-594.1979 | DOI Listing |
Cureus
September 2024
Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, IRQ.
Buccal candidiasis has become increasingly prevalent in recent years, with being the primary causative organism. While systemic fluconazole is an effective treatment, its use is associated with adverse effects such as gastric upset, hepatic failure, and potential drug interactions. Therefore, the development of local fluconazole treatment presents a promising solution to these challenges.
View Article and Find Full Text PDFJ Chem Inf Model
August 2024
Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary.
Fungal infections with high mortality rates represent an increasing health risk. The antifungal protein 2 (NFAP2) is a small, cysteine-rich, cationic protein exhibiting potent anti- activity. As the underlying mechanism, pore formation has been demonstrated; however, molecular level details on its membrane disruption action are lacking.
View Article and Find Full Text PDFDalton Trans
July 2024
Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via L. Borsari 46, 44121 Ferrara, Italy.
Antimicrobial peptides are promising alternatives to classical antibiotics. Their microbicidal activity can arise from different mechanisms, one of which is known as nutritional immunity and has metal micronutrients and metal-binding biomolecules as its main players. Calcitermin is an antimicrobial peptide and an effective metal chelator.
View Article and Find Full Text PDFIn Silico Pharmacol
May 2024
Department of Chemistry, Chettinad College of Engineering and Technology, Karur, Tamilnadu India.
The continuous search for more effective options against well-known pathogens such as remains the rationale for the search for novel lead compounds from various sources. This study aims to investigate the chemical structure, chemical properties, of 5-(2-((5-(((1S,3R) -3-(5-acetamido-1,3,4-thiadiazolidin-2-yl) cyclopentyl) methyl)-1,3,4-thiadiazolidin-2-yl)amino)-2-oxoethyl)-2-methyl-2,3-dihydro-1H-pyrazol-3-ide designated ATCTP using DFT method ωB97XD/-311 + + g(2d, 2p) and the biological potential of compound ATCTP against using molecular docking and ADMET studies. Geometry optimization was carried out in DMSO, ethanol.
View Article and Find Full Text PDFInt J Nanomedicine
June 2024
Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan.
Background: Due to its prevalence, recurrence, and the emergence of drug-resistance, vaginitis significantly impacts the well-being of women. Although cinnamon essential oil (CEO) possesses antifungal activity, its hydrophobic properties limit its clinical application.
Purpose: To overcome this challenge, a nanoemulsification technology was employed to prepare cinnamon essential oil-nanoemulsion (CEO@NE), and its therapeutic efficacy and action mechanism for vaginitis was investigated in vivo and in vitro.
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