AI Article Synopsis
- Statins are commonly used to manage cholesterol levels and prevent heart disease, but can cause side effects like elevated creatine kinase (CK) levels and muscle pain (myopathy).* -
- A case study highlights a coronary patient whose statin treatment was limited due to high CK levels and muscle issues, which were ultimately linked to an underlying condition (Charcot-Marie-Tooth disease) rather than the statin itself.* -
- The findings suggest that ongoing muscle symptoms in patients on statins may need further neurological evaluation to rule out other disorders, and PCSK9 inhibitors can be a safer alternative treatment in such cases.*
Article Abstract
Background: Statin regimens are essential for managing lipids and preventing cardiovascular diseases, both in primary and secondary prevention, alongside lifestyle changes. There are, however, some side-effects associated with statin intake, such as an elevation of (CK) and myopathy.
Case Description: This case describes a coronary patient with high low-density lipoprotein cholesterol (LDL-C) who was undertreated due to elevated creatine kinase (CK) levels and myopathy initially linked to statin use. A proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) replaced statin therapy; however, the existence of persisting/recurrent symptoms or CK elevation posed the need for further investigation. A neurological examination, an electromyography (EMG), and a nerve conduction study (NCV) revealed an underlying sensorimotor polyneuropathy, probably Charcot-Marie-Tooth disease.
Conclusions: Persistent muscle symptoms in patients receiving statins should not be always attributed solely to statin intake. Further neurological evaluation could reveal underlying hereditary sensorimotor polyneuropathies. PCSK9i could serve as the therapy of choice in such cases, as additional drug-induced myopathy could pose severe problems for those patients. HIPPOKRATIA 2023, 27 (4):155-157.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11451505 | PMC |
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