Exosomes are nano-sized extracellular vesicles (EVs) released by diverse types of cells, which affect the functions of targeted cells by transporting bioactive substances. As the main component of exosomes, non-coding RNA (ncRNA) is demonstrated to impact multiple pathways participating in bone healing. Herein, this review first introduces the biogenesis and secretion of exosomes, and elucidates the role of the main cargo in exosomes, ncRNAs, in mediating intercellular communication. Subsequently, the potential molecular mechanism of exosomes accelerating bone healing is elucidated from the following four aspects: macrophage polarization, vascularization, osteogenesis and osteoclastogenesis. Then, we systematically introduce construction strategies based on modified exosomes in bone regeneration field. Finally, the clinical trials of exosomes for bone healing and the challenges of exosome-based therapies in the biomedical field are briefly introduced, providing solid theoretical frameworks and optimization methods for the clinical application of exosomes in orthopedics.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456177 | PMC |
| http://dx.doi.org/10.1177/20417314241286606 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Aging-Induced Discrepant Response of Fracture Healing is Initiated from the Organization and Mineralization of Collagen Fibrils in Callus.
ACS Biomater Sci Eng
January 2025
Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Fracture healing is a complex process during which the bone restores its structural and mechanical integrity. Collagen networks and minerals are the fundamental components to rebuild the bone matrix in callus. It has been recognized that bone quality could be impaired during aging.
View Article and Find Full Text PDFClinical efficacy of antibiotic-loaded bone cement and negative pressure wound therapy in multidrug-resistant organisms diabetic foot ulcers: a retrospective analysis.
Front Cell Infect Microbiol
January 2025
Department of Orthopedics, Fuyang City People's Hospital, Fuyang, China.
Objective: The purpose of this study was to investigate the clinical efficacy of antibiotic-loaded bone cement (ALBC) combined with Negative pressure wound therapy (NPWT) aspiration technique in the treatment of multidrug-resistant diabetic foot ulcers (MDRO-DFUs).
Methods: A retrospective analysis of the clinical data of 80 patients with MDROs-DFU who were used Vacuum sealing drainage (VSD) as NPWT excipient and met the inclusion criteria from January 2019 to January 2024 at our hospital. Patients were divided into an experimental group and a control group, with 40 cases in each.
Effect of "platelet rich" fibrin with bone marrow aspirate on the regenerative capacity of alveolar bone grafting with iliac bone graft: A randomized controlled trial.
Natl J Maxillofac Surg
November 2024
Department of Oral and Maxillofacial Surgery, SDM Craniofacial Unit, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India.
Objectives Of The Study: (1) To evaluate the effect of platelet-rich fibrin (PRF) with bone marrow aspirate on regenerative capacity in patients undergoing iliac bone grafting for secondary alveolar bone grafting. (2) and to compare it with group 2 where only bone marrow aspirate was used along with iliac bone graft in secondary alveolar bone grafting.
Materials And Methods: A prospective study on patients with cleft alveolus, requiring bone grafting and reporting to our unit from October 2018 to October 2020 was included in this study.
Immediate dental implant placement with and without Platelet-Rich Fibrin (PRF) in esthetic zone: A comparative study.
Natl J Maxillofac Surg
November 2024
Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India.
Context: Biomaterials such as platelet-rich fibrin (PRF) have shown to improve healing and osseointegration.
Aims: The aim of this study was to clinically and radiographically evaluate and compare immediate implants placed with and without PRF.
Settings And Design: This prospective and comparative study was conducted among 30 patients in the Department of Oral and Maxillofacial Surgery, Govt.
Comparative evaluation of submerged versus nonsubmerged dental implants - A prospective, clinico-radiographic, split-mouth study.
Natl J Maxillofac Surg
November 2024
Department of Oral and Maxillofacial Surgery, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.
Background: To minimize the risk of impaired osseointegration historically, it has been recommended to insert the implant into the bone (submerged implants) and to allow for submerged healing of 3-6 months in the lower and upper jaw, this conventional technique is advocated. The concept of nonsubmerged healing was introduced in 1988 in which gingival former was placed at the time of implant placement instead of cover screw. The treatment concept of nonsubmerged implant placement enables early implant loading, one surgical procedure only, and a reduced treatment period for the patients.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!