Malignant Mesothelioma: Overcoming Diagnostic Hurdles.

Cureus

Department of Pathology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.

Published: September 2024

AI Article Synopsis

  • Malignant pleural mesothelioma (MM) is a severe cancer often caused by asbestos exposure and is typically diagnosed at later stages.
  • A 58-year-old mason experienced symptoms such as chest pain, shortness of breath, and weight loss, leading to imaging tests that showed abnormalities in the pleura and lymph nodes.
  • Despite initial negative biopsy results, MM was confirmed through a targeted ultrasound-guided biopsy of a lymph node, using specific staining to identify the cancer cells.

Article Abstract

Malignant pleural mesothelioma, an aggressive neoplasm frequently linked to asbestos exposure, is often detected at an advanced stage. This report details the case of a 58-year-old mason who presented with left-sided chest pain, and shortness of breath, accompanied by weight loss for a month. A positron emission tomography (PET) scan revealed increased uptake along the pleural surface, as well as in several mediastinal lymph nodes and the left supraclavicular lymph node. Thoracoscopy revealed the presence of multiple nodules on the costal pleura. Despite repeated negative results from pleural effusion cytology, cell block analysis, and pleural biopsies, the diagnosis of malignant mesothelioma (MM) was ultimately established through an ultrasound-guided (USG) biopsy of the left supraclavicular lymph node, with immunohistochemical confirmation using calretinin.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455275PMC
http://dx.doi.org/10.7759/cureus.68718DOI Listing

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