The parotid, submandibular, and sublingual salivary glands are the major salivary glands in the mouth. Cancers that arise in these glands are relatively uncommon, usually benign, and rarely metastasize. We present a unique case of a 17-year-old male diagnosed with high-grade secretory carcinoma of the salivary gland that was generally asymptomatic except for a persistent rash. The patient reported no significant past medical, family, or social history. A multidisciplinary team efficiently diagnosed and treated the cancer with histopathology, MRI, tumor excision, lymphadenectomy, and adjuvant treatment. Despite the rarity of the cancer, which was found in a high-grade regionally advanced disease, in an uncharacteristically young patient, the patient was effectively treated with adjuvant chemoradiotherapy without treatment-related complications.
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http://dx.doi.org/10.7759/cureus.68823 | DOI Listing |
J Liq Biopsy
December 2024
Dr. Nasser Ibrahim Al-Rashid Orbital Vision Research Center, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Adenoid cystic carcinoma (ACC) is a rare and lethal malignancy that originates in secretory glands of the head and neck. A prominent molecular feature of ACC is the overexpression of the proto-oncogene MYB. ACC has a poor long-term survival due to its high propensity for recurrence and protracted metastasis.
View Article and Find Full Text PDFZhongguo Fei Ai Za Zhi
November 2024
College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China.
Background: The early stages of tumor bone metastasis are closely associated with changes in the vascular niche of the bone microenvironment, and abnormal angiogenesis accelerates tumor metastasis and progression. However, the effects of lung adenocarcinoma (LUAD) cells reprogrammed by the bone microenvironment on the vascular niche within the bone microenvironment and the underlying mechanisms remain unclear. This study investigates the effects and mechanisms of LUAD cells reprogrammed by the bone microenvironment on endothelial cells and angiogenesis, providing insights into the influence of tumor cells on the vascular niche within the bone microenvironment.
View Article and Find Full Text PDFAging (Albany NY)
January 2025
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.
Exposure to ionizing radiation (IR), both low-LET (e.g., X-rays, γ rays) and high-LET (e.
View Article and Find Full Text PDFAnim Cells Syst (Seoul)
January 2025
Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, Korea.
Interferon gamma (IFNγ) is well-known for its ability to stimulate immune cells in response to pathogen infections and cancer. To develop an effective cancer therapeutic vaccine, CT26 colon carcinoma cells were genetically modified to express IFNγ either as a secreted form (sIFNγ) or as a membrane-bound form. For the membrane-bound expression, IFNγ was fused with Fas (mbIFNγ/Fas), incorporating the extracellular cysteine-rich domains, transmembrane, and cytoplasmic domains of Fas.
View Article and Find Full Text PDFEnviron Health Prev Med
January 2025
Health and Environmental Risk Division, National Institute for Environmental Studies.
Background: Chronic arsenite exposure has been known to induce cancer in various organs; however, the underlying mechanisms remain elusive. The characteristic feature of carcinogenesis due to arsenic exposure is that the disease develops after a prolonged latent period, even after cessation of exposure. Our previous study revealed that arsenite exposure induces premature senescence in hepatic stellate cells and suggests that the senescence-associated secretory phenotype (SASP) factors from the senescent cells promote hepatic carcinogenesis.
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