Secretory Carcinoma of the Philtrum of the Upper Lip: A Case Study.

Cureus

Internal Medicine, Southwest Healthcare Medical Education Consortium, Temecula, USA.

Published: September 2024

The parotid, submandibular, and sublingual salivary glands are the major salivary glands in the mouth. Cancers that arise in these glands are relatively uncommon, usually benign, and rarely metastasize. We present a unique case of a 17-year-old male diagnosed with high-grade secretory carcinoma of the salivary gland that was generally asymptomatic except for a persistent rash. The patient reported no significant past medical, family, or social history. A multidisciplinary team efficiently diagnosed and treated the cancer with histopathology, MRI, tumor excision, lymphadenectomy, and adjuvant treatment. Despite the rarity of the cancer, which was found in a high-grade regionally advanced disease, in an uncharacteristically young patient, the patient was effectively treated with adjuvant chemoradiotherapy without treatment-related complications.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456339PMC
http://dx.doi.org/10.7759/cureus.68823DOI Listing

Publication Analysis

Top Keywords

secretory carcinoma
8
salivary glands
8
carcinoma philtrum
4
philtrum upper
4
upper lip
4
lip case
4
case study
4
study parotid
4
parotid submandibular
4
submandibular sublingual
4

Similar Publications

Circulating Adenoid Cystic Carcinoma associated MYB transcripts enable rapid and sensitive detection of metastatic disease in blood liquid biopsies.

J Liq Biopsy

December 2024

Dr. Nasser Ibrahim Al-Rashid Orbital Vision Research Center, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

Adenoid cystic carcinoma (ACC) is a rare and lethal malignancy that originates in secretory glands of the head and neck. A prominent molecular feature of ACC is the overexpression of the proto-oncogene MYB. ACC has a poor long-term survival due to its high propensity for recurrence and protracted metastasis.

View Article and Find Full Text PDF

Background: The early stages of tumor bone metastasis are closely associated with changes in the vascular niche of the bone microenvironment, and abnormal angiogenesis accelerates tumor metastasis and progression. However, the effects of lung adenocarcinoma (LUAD) cells reprogrammed by the bone microenvironment on the vascular niche within the bone microenvironment and the underlying mechanisms remain unclear. This study investigates the effects and mechanisms of LUAD cells reprogrammed by the bone microenvironment on endothelial cells and angiogenesis, providing insights into the influence of tumor cells on the vascular niche within the bone microenvironment.

View Article and Find Full Text PDF

Exposure to ionizing radiation (IR), both low-LET (e.g., X-rays, γ rays) and high-LET (e.

View Article and Find Full Text PDF

The anti-tumor effect of the IFNγ/Fas chimera expressed on CT26 tumor cells.

Anim Cells Syst (Seoul)

January 2025

Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, Korea.

Interferon gamma (IFNγ) is well-known for its ability to stimulate immune cells in response to pathogen infections and cancer. To develop an effective cancer therapeutic vaccine, CT26 colon carcinoma cells were genetically modified to express IFNγ either as a secreted form (sIFNγ) or as a membrane-bound form. For the membrane-bound expression, IFNγ was fused with Fas (mbIFNγ/Fas), incorporating the extracellular cysteine-rich domains, transmembrane, and cytoplasmic domains of Fas.

View Article and Find Full Text PDF

Background: Chronic arsenite exposure has been known to induce cancer in various organs; however, the underlying mechanisms remain elusive. The characteristic feature of carcinogenesis due to arsenic exposure is that the disease develops after a prolonged latent period, even after cessation of exposure. Our previous study revealed that arsenite exposure induces premature senescence in hepatic stellate cells and suggests that the senescence-associated secretory phenotype (SASP) factors from the senescent cells promote hepatic carcinogenesis.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!