"Exploring therapeutic potential and toxicological profiles of species: insights from pharmacological studies and an anti-cholinergic toxicity report.".

Toxicol Res (Camb)

Nashik Gramin Shikshan Prasarak Mandal's, College of Pharmacy, Bramha Valley Educational Campus, (Lit. trans. in English, 'The college of pharmacy, campus for the rural and the village development; Bramha Valley Educational campus, Nashik'.). At, Anjaneri, Trambak, Nashik 422213. Maharashtra, India.

Published: October 2024

AI Article Synopsis

  • The study investigates the therapeutic benefits and toxic risks of various species, focusing on the use of flavonoids to mitigate BPA-induced ovarian damage and the safety of water extracts in specified doses.
  • It also explores interplant communication between soybean and dodder under nutrient deficiency, highlighting protein interactions and insights into the toxicities of dodder in humans.
  • The findings underscore the need for careful consideration of both therapeutic uses and potential toxicological risks, aiming to inform safer practices and guide future research in pharmacology and toxicology.

Article Abstract

This study examines the therapeutic potential and toxicological profiles of species based on recent pharmacological investigations: "a therapeutic potential vs. toxicological risks of species: a pharmacological-toxicology dilemma." The study encompasses diverse research areas, including the mitigation of Bisphenol A (BPA)-induced ovarian damage using flavonoids (CCFs), acute and sub-acute toxicity assessments of water extract (CLW), and observations on toxicity in horses. In addition, this scientific study discusses the interplant communication dynamics between soybean and the parasitic dodder () under nutrient deficiency conditions. Key significant findings highlight the efficacy of CCFs in alleviating BPA-induced ovarian damage, the safety profile of CLW within specified doses, and clinical manifestations of toxicity in horses. Moreover, insights into interplant communication mechanisms emphasise the significance of protein-mediated interactions in nutrient-deficient environments. The report illustrates the potential toxicity of Dodder in humans, and further research findings into its chemical composition and toxicological profiles reveal great data on its phytotoxicity. Greater awareness and understanding of the risks associated with consuming Dodder and other similar plant species are crucial for preventing plant intoxication and have been a significant major focus of the present toxicology study of species. Hence, by addressing these objectives, the scientific study aims to balance the therapeutic benefits of Cuscuta species with their potential toxicological risks, contributing to a more nuanced understanding of their role in pharmacology and toxicology. This dual focus is crucial for guiding future research and informing safe usage practices.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447373PMC
http://dx.doi.org/10.1093/toxres/tfae160DOI Listing

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