Genetic Predisposition for Gynecologic Cancers.

Clin Obstet Gynecol

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Comprehensive Cancer Center, University of Virginia Health, Charlottesville, Virginia.

Published: December 2024

AI Article Synopsis

  • Hereditary cancer syndromes account for up to 10% of all cancers and are often detected after a cancer diagnosis, indicating a need for earlier testing.
  • Primary care providers, especially obstetrician-gynecologists, can play a crucial role in assessing hereditary cancer risks through family history and genetic testing.
  • Identifying hereditary cancer genes can lead to proactive prevention strategies, including better screenings and personalized care plans, particularly for common gynecologic hereditary cancer syndromes.

Article Abstract

Hereditary cancer syndromes (HCS) are responsible for up to 10% of all cancers. At present, the majority of cancer susceptibility testing is initiated after a cancer diagnosis. There exists a significant opportunity for primary care providers including general obstetrician-gynecologists to engage in hereditary cancer risk assessment through adequate family history evaluation, initiation of genetic testing, and following the recommendations of national organizations. Identifying hereditary cancer genes may prompt primary prevention efforts such as enhanced screening, prevention, or personalized care strategies. We will review the literature regarding the approach and assessment of the most common gynecologic HCS.

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Source
http://dx.doi.org/10.1097/GRF.0000000000000894DOI Listing

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