AI Article Synopsis
- A study in Yamagata, Japan, analyzed blood samples from different years (1976-2019) to understand the prevalence of enterovirus D68 (EV-D68), a virus that was uncommon in the 20th century.
- The research found that neutralizing antibody positive rates in people under 20 years increased significantly over the years, suggesting rising exposure to EV-D68.
- The study also indicated that while children show a gradual increase in seroprevalence, adults reach a high plateau, indicating consistent transmission of the virus among children even when it was rarely detected.
Article Abstract
To clarify the epidemiology of enterovirus D68 (EV-D68), an enterovirus rarely identified in the 20th century, we performed seroepidemiological analysis against EV-D68 using sera collected in 1976, 1985, 1990, 1999, 2009, and 2019, as well as Yamagata isolate (EVD68/Yamagata.JPN/2023-89), in Yamagata, Japan. The neutralizing antibody (Ab)-positive rates for those under 20 years old were 61.0%, 82.5%, 84.3%, 46.7%, 50.5%, and 67.9%, in each year, whereas the rates for those above 20 years old were between 93.4% and 99.1%. Generally, geometric mean titers (GMTs）increased with age among children and the total GMT in each year was 25.4, 49.2, 37.2, 30.8, 29.5, and 33.9, from 1976 to 2019, respectively. The findings in this Yamagata-based study showed that the seroprevalence of EV-D68 over the last four decades has increased with age among children, as a susceptible group, and then reaches a plateau of over approximately 80% among adults. This study clearly revealed that EV-D68 was stably transmitted among children in the 20th century, when EV-D68 detection was quite rare.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jmv.29947 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Human enteroviruses and the long road to acute flacid paralysis eradication.
J Appl Microbiol
December 2024
Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology.
Enteroviruses (EV) are a highly diverse group of viruses multiplying primarily in the gastrointestinal tract and/or the upper respiratory tract, initially distributed in two separate genera: Enterovirus and Rhinovirus, respectively. According to the similarities in genome organization and particle structure, rhinovirus species were later reclassified as also belonging to genus Enterovirus. Human EV infections are usually asymptomatic or causing mild clinical manifestations.
View Article and Find Full Text PDFPrevalence and Phylogenetic Analysis of Rhinoviruses in Patients with Acute Respiratory Infections and Community-Acquired Pneumonia in a Referral Hospital, Tehran, Iran.
Tanaffos
January 2024
Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Rhinoviruses are known as the leading pathogens of respiratory diseases. Determining the prevalence and phylogeny of rhinoviruses plays a pivotal role in producing vaccines and medications and preventing virus complications. This study investigated the frequency, and genetic variation of rhinoviruses detected in patients referred to Masih Daneshvari Hospital.
View Article and Find Full Text PDFEmerging Therapeutics in the Fight Against EV-D68: A Review of Current Strategies.
Influenza Other Respir Viruses
December 2024
Infection and Immunity Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.
Enterovirus-D68 (EV-D68) was first identified in 1962 in pediatric patients with acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV-D68 was underestimated due to limited data and serotyping methods. In 2014, the United States experienced outbreaks of acute flaccid myelitis (AFM) in children EV-D68 positive.
View Article and Find Full Text PDFA Systematic Review on the Antimicrobial Activity of Andrographolide.
J Microbiol Biotechnol
November 2024
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.
Andrographolide, a bioactive compound from Andrographis paniculata, has gained attention for its antimicrobial properties, which include antibacterial, antiviral, antifungal, and antiprotozoal effects. As an herbal extract used in traditional medicines, andrographolide also shows promise for developing new antimicrobial agents, especially in the fight against rising antimicrobial resistance. Following the PRISMA 2020 guidelines, 16 peer-reviewed studies published from 2010 to 2024 and focusing on andrographolide's effects on bacteria, viruses, fungi, and protozoa were reviewed.
View Article and Find Full Text PDFMitophagosomes induced during EV-D68 infection promote viral nonlytic release.
bioRxiv
December 2024
Department of Microbiology and Immunology and Center for Pathogen Research, University of Maryland School of Medicine, 685 W. Baltimore Avenue, Baltimore, MD 21201, USA.
Enterovirus-D68 (EV-D68) is a plus-strand RNA virus that primarily causes infant respiratory infections. In rare pediatric cases, infection with EV-D68 has been associated with acute flaccid myelitis, a polio-like paralytic disease. We have previously demonstrated that EV-D68 induces nonselective autophagy for its benefit.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!