AI Article Synopsis
- - MELAS syndrome is caused by a mitochondrial DNA mutation that affects the modification of tRNA, leading to problems with energy production in cells.
- - This condition results in issues such as muscular weakness, brain dysfunction, increased lactic acid, and episodes resembling strokes.
- - High-dose taurine supplementation has shown potential in clinical trials, helping to reduce stroke-like episodes and enhance cellular function in affected patients.
Article Abstract
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is characterized by a mitochondrial DNA mutation that leads to defective taurine modification of the leucine tRNA anticodon, with consequent impaired translation of the UUG codon. This defect reduces synthesis of respiratory chain complexes, which causes energy failure. Taurine supplementation improved mitochondrial function in MELAS model cells. A physician-initiated clinical trial reported that high-dose taurine supplementation therapy suppressed stroke-like episodes and improved taurine modification rates in leukocytes.
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| http://dx.doi.org/10.11477/mf.1416202748 | DOI Listing |
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