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Trastuzumab deruxtecan in human epidermal growth factor receptor 2-positive breast cancer brain metastases: A systematic review and updated meta-analysis.
Cancer Treat Rev
January 2025
Division of Hematology and Oncology, University of Virginia Comprehensive Cancer Center, Charlottesville, VA, United States. Electronic address:
Background: Trastuzumab deruxtecan (T-DXd) has shown promising activity in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) and central nervous system (CNS) involvement. In this updated meta-analysis, we explore the effectiveness of T-DXd in a large subset of patients with HER2-positive BC and CNS disease.
Methods: A systematic search was made on September 16th, 2024, for studies investigating T-DXd in the scenario of HER2-positive BC and brain metastases (BMs) and/or leptomeningeal disease (LMD).
Emergency managers' challenges with wildfires and related cascading hazards in California.
J Environ Manage
January 2025
Department of Psychological Science, University of California, Irvine, CA, 92697, USA; Department of Medicine, University of California, Irvine, CA, 92697, USA; Department of Health, Society, and Behavior, University of California, Irvine, CA, 92697, USA; Department of Population Health and Disease Prevention, University of California, Irvine, CA, 92697, USA.
This study investigates the complexities faced by emergency managers in wildfire-prone areas to uncover pressing issues and potential solutions. Four themes are discerned through three focus group discussions with emergency managers from nine counties across California. First, there is unequal access to resources for both risk assessment and response, with counties that have fewer resources facing significant challenges in effectively managing wildfire risks.
View Article and Find Full Text PDFImpacts of climate change on storm event-based flow regime and channel stability of urban headwater streams.
J Environ Manage
January 2025
Tetra Tech, Inc., P.O. Box 14409, Research Triangle Park, NC, 27709, United States. Electronic address:
Due to the recent improved availability of global and regional climate change (CC) models and associated data, the projected impact of CC on urban stormwater management is well documented. However, most studies are based on simplified design storm analysis and unit-area runoff models; evaluations of the long-term, continuous hydrologic response of extensive stormwater control measures (SCM) implementation under future CC scenarios are limited. Moreover, channel stability in response to CC is seldom evaluated due to the input data required to develop a long-term, continuous sediment transport model.
View Article and Find Full Text PDFThe impact of air pollution on acute angle-closure glaucoma in Hefei, China, 2017-2022: a time-series study.
J Occup Environ Med
November 2024
Department of Ophthalmology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Objective: The study investigated the effects of air pollutants on the incidence of acute angle-closure glaucoma (AACG) in Hefei, China.Methods: A combination of generalized additive models (GAM) and distributed lag non-linear models (DLNM) was used to explore the relationship between air pollutants and the incidence of AACG.Results: Exposure-response curves showed that exposure to PM2.
View Article and Find Full Text PDFRecurrent adamantinomatous craniopharyngioma stabilized with tocilizumab and bevacizumab: illustrative case.
J Neurosurg Case Lessons
January 2025
Department of Neurology, Mayo Clinic, Rochester, Minnesota.
Background: Adamantinomatous craniopharyngiomas (ACPs) are slow-growing, cystic, highly morbid central nervous system tumors located adjacent to vital structures including the pituitary, hypothalamus, and optic chiasm. Tumor recurrence is common. Treatment relies on resection with or without adjuvant radiation and is highly individualized.
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