Background: As India progresses towards TB elimination five years ahead of Sustainable Development Goals (SDG), Community-based perceptions of tuberculosis stigma become particularly relevant in the context of TB elimination efforts. This study aims to assess the cross-cultural reliability of 'Community Perspectives Van Rie TB Stigma Scale' which can been used for screening and rapid evaluation of prevalent stigma themes in community.
Methods: A community based cross-sectional study was conducted in North India among 400 TB survivors to assess the cross-cultural reliability of 'Community Perspective Van Rie TB stigma Scale'. Cronbach Alpha and McDonald's Omega were used for reliability analysis.
Results: Cronbach ɑ value for the Van Rie TB Stigma Scale was 0.826 and McDonald's ω is 0.832 indicative of good reliability of the TB Stigma Scale.
Conclusion: The study is one the first studies to assess the cross-cultural reliability of Community Perspective of Van Rie TB Stigma Score in India. The reliability analysis indicates that the 'Community Perspectives Van Rie TB Stigma Scale' can be used in the Indian settings for screening of TB associated stigma.
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http://dx.doi.org/10.1016/j.ijtb.2024.08.009 | DOI Listing |
Antimicrob Agents Chemother
December 2024
Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Bedaquiline (BDQ) is crucial for the treatment of rifampicin-resistant tuberculosis, yet resistance threatens its effectiveness, mainly linked to mutations in the () gene. While frameshift mutations are thought to produce non-functional proteins, we hypothesize that they can result in conserved proteins through late-stop codons or alternative reading frames and remain BDQ susceptible. We extracted 512 isolates harboring frameshift mutations in from the World Health Organization (WHO) catalog and 68 isolates with minimum inhibitory concentration (MIC) in mycobacterial growth indicator tube (MGIT) through a literature review.
View Article and Find Full Text PDFIJTLD Open
September 2024
Department of Family Medicine and Population Health, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Background: Accurate diagnosis of bedaquiline (BDQ) resistance remains challenging. A Bayesian approach expresses this uncertainty as a probability of BDQ resistance (prBDQ) with a 95% credible interval. We investigated how prBDQ information influences BDQ prescribing decisions.
View Article and Find Full Text PDFPLoS One
September 2024
Torch Consortium FAMPOP Faculty of Medicine and Health Sciences, University of Antwerp, Antwerpen, Belgium.
PLoS One
June 2024
Department of Family Medicine and Population Health, Global Health Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Lancet Infect Dis
October 2024
Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
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