AI Article Synopsis
- This study looked at the safety and effectiveness of a treatment called Gamma-knife stereotactic radiosurgery (SRS-GK) for a type of brain tumor called radiation-induced meningiomas (RIMs) at a hospital in Italy.
- They included data from 13 patients and found that 26% improved, while 52% stayed the same and 22% got worse, with a good control rate over 5 years.
- In a bigger analysis, including 146 patients, the overall success rate was high, but some patients experienced side effects like swelling, showing that while SRS-GK works well, there can be risks involved.
Article Abstract
This is a single-center experience and metanalysis of the safety and efficacy measures of Gamma-knife stereotactic radiosurgery (SRS-GK) for radiation-induced meningiomas (RIMs). This study comprised a single-center analysis of SRS-GK for RIMs at IRCCS San Raffaele Hospital, Milan, Italy, and a systematic literature review and meta-analysis to address the actuarial local control (LC), distant control (DC), progression-free survival (PFS), and toxicity. The original series comprised 13 patients harboring 30 RIMs. Partial response was observed in 26 %, stability in 52 %, and progression in 22 %. The 5-year LC and DC rates were 71 % and 67 %. One patient developed radionecrosis, and an additional 2 presented edema. Metanalysis comprised 4 papers and data from the original series, comprising 146 patients and 308 RIMs. The 5-year LC was 84 %, the DC 67 %, and radionecrosis in 1.4 %. SRS-GK has an efficacy profile falling between that observed for radiologically suspected sporadic meningiomas and confirmed higher-grade lesions.
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| http://dx.doi.org/10.1016/j.critrevonc.2024.104526 | DOI Listing |
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