AI Article Synopsis
- Scientists have studied how to treat post-traumatic stress disorder (PTSD) but current methods only help 60% of people.
- Allopregnanolone, a chemical in our body, might help with PTSD by affecting stress and fear.
- Researchers think allopregnanolone could be a new way to treat PTSD and want to study it more.
Article Abstract
Significant amounts of research have been devoted to treatment of post-traumatic stress disorder (PTSD) and the understanding of its fear and stress-related symptoms. However, current interventions are only effective in 60 % of the patient population. Allopregnanolone has become a topic of interest for PTSD due to its influences on inhibitory neurotransmission and the physiological stress response. This review explores available literature that suggests that allopregnanolone has an influence on (a) chronic stress and anxiety-like symptoms, (b) fear conditioning and contextual fear, and (c) intrusive and emotional memories. A relationship between allopregnanolone and PTSD is suggested, postulating that allopregnanolone is a potential target for the treatment of PTSD. This very exciting prospect calls for the expansion of research investigating a direct relationship between allopregnanolone and PTSD.
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| http://dx.doi.org/10.1016/j.pnpbp.2024.111168 | DOI Listing |
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