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School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, LE11 3TU, UK.
Published: October 2024
AI Article Synopsis
Trimethylamine N-oxide (TMAO) is linked to bad heart health and is produced by gut bacteria, but how exercise affects its production is unclear.
The study looked at how a single session of intermittent exercise influences TMAO production from choline intake in young, healthy individuals.
Results showed that TMAO levels increased similarly whether choline was taken after exercise or after resting, indicating exercise doesn't change gut bacteria's behavior regarding TMAO production.
Article Abstract
Introduction: Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown.
Objectives/methods: This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort.
Results: Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period.
Conclusion: This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.
